View Article

  • A Review On Omaveloxolone
  • 1Assistant Professor, Department of Pharmaceutics, Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303.
    2Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

Abstract

Omaveloxolone is a semisynthetic triterpenoid used to treat friedreich’s ataxia. It is the second generation oleananetriterpenoid Nrf2 inducer with antioxidant and anti-inflammatory properties. It is currently used to test in medical trials for freidreich’s ataxia, a genetic, multi –organ disease involving mitochondrial dysfunction. It is a nuclear factor erythroid 2 related factor 2 (Nrf2) activator. It is reviewed under Food and Drug Administration and it has the potential to first approved treatment for friedreich’s ataxia. Omaveloxolone is not the cure for friedreich’s ataxia, it is the first agent targeting to reach NDA submission. It is the rational and potent therapy that is probably disease modifying in the treatment of friedreich’s ataxia. Omaveloxolone (RTA-408) is an Nrf2 activator, which decreases the susceptibility of cells through oxidative stress and it leads to cell death and tissue degradation. It is good tolerated not having any significant long term adverse effects. Treatment with RTA-408 remarkably improved in the neurological function, it is measured by modified Freidreich’s Ataxia Rating Scale.

Keywords

Omaveloxolone

Reference

  1. Michael S, Petrocine SV, Qian J, Lamarche JB, Knutson MD, Garrick MD, Koeppen AH. Iron and iron- responsive proteins in the cardiomyopathy of Friedreich’s ataxia. Cerebellum. 2006; 257 (5): 61–67.
  2. Harding AE. Friedreich’s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain. 1981; 104: 589–620.
  3. Weidemann F, Rummey C, Bijnens B, Stork S, Jasaityte R, Dhooge J, Baltabaeva A, Sutherland G, Schulz JB, Meier T. Mitochondrial Protection with Idebenone in Cardiac or Neurological Outcome study: The heart in Friedreich ataxia: definition of cardiomyopathy, disease severity, and correlation with neurological symptoms. Circulation. 2012; 125: 1626–34.
  4. Alexeev V, Lash E, Aguillard A et al. (2014) Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound. Molecular cancer therapeutics 13, 2968-2977.
  5. Harding AE. Friedreich’s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain 1981; 104 (3): 589–620.
  6. Babady NE, Carelle N, Wells RD, et al. Advancements in the pathophysiology of Friedreich’s ataxia and new prospects for treatments. Mol Genet Metab 2007; 92 (1–2): 23–35.
  7. Shan Y, Schoenfeld RA, Hayashi G, et al. Frataxin deficiency leads to defects in expression of antioxidants and Nrf2 expression in dorsal root ganglia of the Friedreich’s ataxia YG8R mouse model. Antioxid Redox Signal 2013; 19 (13):1481–1493.
  8. D’Oria V, Petrini S, Travaglini L, et al. Frataxin deficiency leads to reduced expression and impaired translocation of NF-E2-related factor (Nrf2) in cultured motor neurons. Int J Mol Sci 2013; 14(4): 7853–7865.
  9. Paupe V, Dassa EP, Goncalves S, et al. Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia. PLoS One 2009; 4 (1): 4253.
  10. Lynch DR, Chin MP, Delatycki MB, et al. Safety and efficacy of Omaveloxolone in Friedreich ataxia (MOXIe study). Ann Neurol 2021; 89 (2): 212–225.
  11. Abeti R, Baccaro A, Esteras N, et al. Novel Nrf2-inducer prevents mitochondrial defects and oxidative stress in Friedreich’s Ataxai models. Front Cell Neurosci 2018; 12:188.
  12. Harding AE. Friedreich’s ataxia: a clinical and genetic study of 90 families with an analysis of early diagnostic criteria and intrafamilial clustering of clinical features. Brain 1981; 104(3): 589–620.

Photo
Lalitha A.
Corresponding author

Assistant Professor, Department of Pharmaceutics, Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303.

Photo
Nanjundeshwari G.
Co-author

Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

Photo
Swetha M.
Co-author

Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

Photo
Swetha R.
Co-author

Vivekanandha Pharmacy College for Women, Veerachipalayam, Sankagiri West, Sankagiri Taluk, Salem District-637303

Lalitha A., Nanjundeshwari G., Swetha M., Swetha R., A Review On Omaveloxolone, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 447-456. https://doi.org/10.5281/zenodo.8383431

More related articles
Delonix regia's Potential Health Benefits: Investi...
Shashank Tiwari, Shreya Talreja, ...
Anti-Diarrheal and Anti-Ulcer Effect of 70% Ethano...
Irfan Soyel, Malay Besra, Sumit Maji, Biplab Kumar Chakra, Nilanj...
Unveiling The Therapeutic Potential Of Thiazoles: ...
V. S. Anjana, S. R. Anchu, V. S. Athira, Rachel Mathew, ...
Comprehensive Phytochemical Profiling And Therapeutic Applications Of Plecosperm...
Dr. Mallappa Shalavadi, Devraj Chavan, Shivaraj Hiremath, Vinayaka Madivalar, Shubham Teli, ...
A Review On: Antifungal And Antibacterial Activity Of 1, 3, 4-Oxadiazole Derivat...
Rupesh ramrao shinde , Abhiman. S Jadhav, V. Y. Lokhande, Pratik S. Dhramasale , ...
A Review On Development And Validation Of Ultra Performance Liquid Chromatograph...
Kanchan Shinde, Neha Gaikwad, Varsha Pangale, Charushila Bhangale, ...
Related Articles
To Formulate And Evaluate Herbal Hair Oil For Healthier Hair ...
Chand Pravin Dnyandeo , V. R. Muley, Prachi P. Udhapurkar , Ghule Govind Arjun, ...
Understanding Monkey pox: A Comparative Analysis with Other Poxviruses and Envir...
Yamin Ansari, Ashwini Pawar, Krutika Channe, Vinod Thakare, ...
Formulation And Evaluation of Moisturising Cream Containing Coriander Leaves Ext...
Mariyambi K. V., Aswathi V. V., Ismail M., Nafeesath K. P., Shahala, Shamna K., ...
An Analysis Of The Effect Of Naturopathy And Ayurveda On Cystic Fibrosis ...
Rutuja Damodhar Amle, Ravindra Mapari , Harshal Sudhakar Lahane . , Yogesh Bhagwan Katkar, Vitthal G...
More related articles
Anti-Diarrheal and Anti-Ulcer Effect of 70% Ethanolic Extract of Paederia foetid...
Irfan Soyel, Malay Besra, Sumit Maji, Biplab Kumar Chakra, Nilanjan Adhikari , ...
Unveiling The Therapeutic Potential Of Thiazoles: A Review Of Their Biological A...
V. S. Anjana, S. R. Anchu, V. S. Athira, Rachel Mathew, ...
Anti-Diarrheal and Anti-Ulcer Effect of 70% Ethanolic Extract of Paederia foetid...
Irfan Soyel, Malay Besra, Sumit Maji, Biplab Kumar Chakra, Nilanjan Adhikari , ...
Unveiling The Therapeutic Potential Of Thiazoles: A Review Of Their Biological A...
V. S. Anjana, S. R. Anchu, V. S. Athira, Rachel Mathew, ...