A Review on Green Chemistry: A Sustainable Approach to Chemical Innovation

Mane Kota Vinay Kumar, Nagidi Devi, Kinjarapu Jothirmae, Kukala Lavanya Jyothi, Ravula Tulasi Naga Pavan Kumar, Gedda Venkatesh,

doi:10.5281/zenodo.14988326

Review Paper | Open Access
Volume 03 | Issue 03 | Article Id IJPS/250302270

A Review on Green Chemistry: A Sustainable Approach to Chemical Innovation
Mane Kota Vinay Kumar* Nagidi Devi Kinjarapu Jothirmae Kukala Lavanya Jyothi Ravula Tulasi Naga Pavan Kumar Gedda Venkatesh
Dr. C.S.N Institute of Pharmacy Near Industrial Estate Bhimavaram 534203.

Abstract

Green chemistry, also known as sustainable chemistry, aims to design chemical products and processes that minimize environmental impact while improving efficiency and safety. This review discusses the principles of green chemistry, its significance in reducing hazardous waste, and various applications across industries. The future prospects and challenges in implementing green chemistry are also explored.

Keywords

Green Chemistry, Sustainable Chemistry, Environmental Protection, Atom Economy, Renewable Feedstocks, Catalysis, Biodegradable Polymers, Waste Reduction, Energy Efficiency, Pollution Prevention

Introduction

Green chemistry, also referred to as sustainable chemistry, is a scientific discipline focused on developing chemical products and processes that reduce or eliminate the use and generation of hazardous substances. The primary goal of green chemistry is to minimize the adverse impact of chemical practices on human health and the environment. This approach emerged in response to increasing concerns about environmental pollution, resource depletion, and health risks associated with conventional chemical processes. Paul Anastas and John Warner formulated twelve principles of green chemistry, which serve as a framework for designing safer, more sustainable chemical methodologies. These principles emphasize waste prevention, the use of non-toxic and renewable materials, energy efficiency, and the development of environmentally benign solvents and reagents. By following these guidelines, researchers and industries can enhance process efficiency while reducing ecological harm. A key aspect of green chemistry is the consideration of a chemical product’s entire life cycle—from synthesis and usage to disposal. This holistic perspective ensures that the environmental footprint is minimized at every stage, promoting long-term sustainability. Industries such as pharmaceuticals, agriculture, and materials science are increasingly adopting green chemistry principles to develop safer drugs, biodegradable polymers, eco-friendly pesticides, and renewable feedstocks. The integration of green chemistry into industrial practices is crucial for addressing global challenges, including pollution, climate change, and resource scarcity. As the field continues to evolve, it fosters innovation in sustainable technologies, enhances industrial responsibility, and supports economic viability. The widespread adoption of green chemistry not only benefits the environment but also contributes to a more sustainable and resilient chemical industry.

Principles of Green Chemistry

Green chemistry is governed by 12 key principles, which include:

Table 1 Twelve Principles of Green Chemistry

No.	Principle	Description of Principle	Example
1	Prevention	Avoiding waste generation is preferable to treating or disposing of waste after its formation.	Using atom-efficient reactions like the Haber-Bosch process to optimize nitrogen and hydrogen usage in ammonia synthesis.
2	Atomic Economy	Synthetic methods should be designed to incorporate all materials into the final product, minimizing waste.	Addition reactions like ethene bromination: C₂H₄+Br₂→C₂H₄Br₂ensure full atom utilization.
3	Safer Chemical Synthesis	Reactions should generate substances with low toxicity to humans and the environment.	Using hydrogen peroxide (H?O?) instead of chlorine for paper bleaching: H₂O₂→H₂O+[O]
4	Safer Chemicals Design	Chemicals should be effective yet non-toxic to minimize hazards.	Ibuprofen green synthesis (BHC Process) increases yield while reducing waste.
5	Use of Safer Solvents & Auxiliaries	The use of solvents and other auxiliary chemicals should be avoided or made safer.	Using water or supercritical CO? instead of hazardous organic solvents in extractions and reactions.
6	Energy Efficiency	Chemical processes should minimize energy consumption, preferably operating at room temperature and pressure.	Biocatalysis with enzymes, such as lipase-catalyzed esterification, eliminates the need for high-temperature reactions.
7	Use of Renewable Raw Materials	Whenever possible, renewable raw materials should be used instead of non-renewable ones.	Producing polylactic acid (PLA) from corn starch rather than petroleum-based plastics.
8	Reduction of Derivatives	Unnecessary derivatization (e.g., protection/deprotection steps) should be minimized to avoid extra waste.	Direct amination of alcohols to form amines instead of multi-step transformations: R−OH+NH₃→R−NH₂+H₂O
9	Catalysis	Catalytic reactions are more efficient and generate less waste than stoichiometric reactions.	Palladium-catalyzed Suzuki coupling reaction: Ar−B(OH)₂+Ar′−X→Ar−Ar′+HX
10	Degradation Products Design	Chemicals should degrade into harmless products after use rather than persist in the environment.	Biodegradable plastics (PHA, PLA) decompose naturally: (C₃H₄O₂)n+H₂O→CO₂+H₂O
11	Real-Time Analysis for Pollution Prevention	Analytical methods should be developed for real-time monitoring to prevent hazardous byproducts.	Monitoring CO emissions in catalytic converters using spectroscopy: 2CO+O₂→2CO₂
12	Accidents Prevention	Substances and processes should be designed to reduce risks of leaks, explosions, and fires.	Using water-based rather than solvent-based paints to reduce fire hazards in industrial applications.

Solvent Classification and Greener Alternatives

Most traditional organic solvents are highly volatile, leading to air pollution and posing flammability and toxicity hazards. Consequently, there is a growing emphasis on replacing these solvents with environmentally safer alternatives.

One widely recommended alternative is water, given its non-toxic nature. However, the limited solubility of many organic compounds in water often restricts its use. A more viable option is supercritical carbon dioxide (scCO?), which serves as a green solvent due to its non-toxic properties and the fact that it is derived as a byproduct of industrial processes, thus preventing additional CO? emissions. Additionally, ionic liquids present another promising alternative. They exhibit low volatility, which significantly reduces atmospheric contamination. Unlike conventional solvents, ionic liquids do not readily evaporate, making them more sustainable (Poliakoff and Licence, 2007).

Table 2 solvents and green alternatives:

Solvent Type	Characteristics	Environmental Impact	Green Alternative	Advantages of Green Alternative
Organic Solvents (e.g., benzene, toluene, chloroform)	High volatility, flammable, toxic	Causes air pollution, hazardous waste generation	Water (if applicable)	Non-toxic, abundant, and environmentally friendly
Chlorinated Solvents (e.g., dichloromethane, chloroform)	Persistent, ozone-depleting potential	Highly toxic, bioaccumulative, and carcinogenic	Supercritical CO? (scCO?)	Non-toxic, obtained as a byproduct, does not contribute to climate change
Petroleum-based Solvents (e.g., hexane, heptane)	Derived from non-renewable resources, high toxicity	Contributes to resource depletion and greenhouse gas emissions	Bio-based solvents (e.g., ethyl lactate from corn, terpenes from citrus)	Renewable, biodegradable, and less toxic
Volatile Organic Compounds (VOCs) (e.g., acetone, methanol)	Rapid evaporation, contributes to smog formation	Air pollution, health hazards	Ionic Liquids (ILs)	Low volatility, minimal evaporation, reusable
Polar Aprotic Solvents (e.g., DMSO, DMF)	High solvency power but toxic	Disposal issues, toxic to humans	Deep Eutectic Solvents (DES)	Biodegradable, low toxicity, sustainable
Ethers (e.g., diethyl ether, tetrahydrofuran)	Highly flammable, peroxide-forming	Fire hazards, explosive peroxides formation	Cyclopentyl methyl ether (CPME)	Less peroxide formation, lower toxicity
Glycol Ethers (e.g., ethylene glycol ethers)	High solvency, reproductive toxicity	Toxic to humans, environmental persistence	Green glycol ethers (e.g., propylene glycol ethers)	Lower toxicity, biodegradable
Aromatic Solvents (e.g., xylene, styrene)	High solvency power, neurotoxic	Air pollution, hazardous waste	Green aromatic solvents (e.g., p-cymene from citrus)	Renewable, low toxicity, biodegradable
Ketones (e.g., methyl ethyl ketone)	Strong solvent, flammable	Air pollution, contributes to smog	Bio-based ketones (e.g., 2-methyl tetrahydrofuran from biomass)	Renewable, lower toxicity
Amides (e.g., N-methyl-2-pyrrolidone, DMF)	High solvency, toxic	Carcinogenic, reproductive toxicity	Cyrene™ (bio-based solvent from cellulose)	Renewable, non-toxic, biodegradable
Alcohols (e.g., isopropanol, ethanol)	Flammable, moderate toxicity	Air pollution, energy-intensive production	Green alcohols (e.g., bioethanol)	Renewable, lower environmental impact
Halogenated Solvents (e.g., carbon tetrachloride)	Persistent, toxic, ozone-depleting	Global warming, bioaccumulation	Fluorinated ethers and HFEs	Lower toxicity, minimal ozone depletion

Green Chemistry Equipment and Their Uses

Green chemistry emphasizes the use of energy-efficient and environmentally friendly equipment to minimize waste and reduce hazardous chemicals in chemical processes.

Table 3 outlining different types of equipment used in green chemistry and their applications:

Equipment	Description & Uses
Microwave Reactor	- Uses microwave energy to accelerate reactions, reducing reaction time and energy consumption. - Enhances yield and selectivity while minimizing waste.
Supercritical Fluid Extractor (SCFE)	- Utilizes supercritical CO? as a solvent for extraction, replacing hazardous organic solvents. - Commonly used in pharmaceuticals, food, and fragrance industries.
Sonochemical Reactor (Ultrasound Reactor)	- Uses ultrasonic waves to enhance reaction rates and efficiency. - Reduces the need for harsh chemicals in synthesis and extraction processes.
Photochemical Reactor	- Employs light energy to drive chemical reactions, reducing the need for toxic reagents. - Applied in organic synthesis, wastewater treatment, and material science.
High-Pressure Hydrogenation Reactor	- Enables hydrogenation reactions under controlled conditions. - Reduces the use of harmful catalysts and improves efficiency.
Ball Mill (Mechanochemical Reactor)	- Uses mechanical force instead of solvents to initiate chemical reactions. - Reduces solvent waste and enhances reaction efficiency.
Plasma Reactor	- Uses plasma energy to drive chemical transformations without harmful chemicals. - Applied in pollution control and material processing.
Electrochemical Reactor	- Utilizes electricity to drive chemical reactions instead of traditional reagents. - Reduces hazardous by-products in oxidation and reduction reactions.
Green Solvent-Based Extraction Systems	- Designed to use bio-based or water-based solvents instead of toxic organic solvents. - Commonly used in herbal extractions and pharmaceutical industries.
Flow Chemistry Systems (Microreactors)	- Enables continuous reactions with precise control over temperature, pressure, and mixing. - Reduces solvent waste and increases safety and efficiency.

Using these green chemistry instruments helps industries reduce pollution, conserve energy, and promote sustainability, making chemical processes eco-friendlier and more efficient.

Green Chemistry and Its Diverse Applications

Green chemistry, also known as sustainable chemistry, is an innovative approach aimed at designing products and processes that minimize the use and generation of hazardous substances. This concept is increasingly applied across various industries, including pharmaceuticals, agrochemicals, materials science, and energy production, to ensure environmental sustainability while enhancing efficiency and safety.

Applications in Pharmaceuticals

In the pharmaceutical industry, green chemistry principles are utilized to develop safer drugs, optimize synthetic routes, and reduce the environmental impact of production processes. Techniques such as catalytic reactions, biocatalysis, solvent-free synthesis, and the use of greener solvents help improve yield, decrease waste, and lower toxicity. Additionally, advancements in flow chemistry and continuous manufacturing contribute to resource efficiency and reduced energy consumption.

Role in Agrochemicals

Green chemistry plays a crucial role in the development of environmentally friendly pesticides, herbicides, and fertilizers. By employing bio-based and biodegradable alternatives, scientists aim to reduce soil and water contamination. The use of precision chemistry techniques ensures targeted action, minimizing the adverse effects on non-target species while enhancing crop protection.Contribution to Materials Science The field of materials science benefits significantly from green chemistry by fostering the development of sustainable polymers, biodegradable plastics, and eco-friendly coatings. Innovations such as bio-based polymers, recyclable composites, and water-based coatings contribute to waste reduction and improved sustainability in industrial applications.

Energy Production and Storage

Green chemistry plays a pivotal role in advancing cleaner energy solutions. The development of biofuels, hydrogen production methods, and energy-efficient batteries is guided by principles of sustainability and reduced environmental impact. Additionally, advancements in carbon capture and utilization (CCU) help mitigate greenhouse gas emissions, promoting a circular economy.

Industrial and Consumer Applications

Beyond pharmaceuticals and energy, green chemistry is widely implemented in industries such as textiles, cosmetics, and packaging. Sustainable dyes, non-toxic personal care products, and biodegradable packaging materials are being developed to reduce the ecological footprint and enhance product safety.

Future Prospects and Challenges

The continued growth of green chemistry depends on overcoming challenges such as the high cost of implementation, the need for industry-wide adoption, and regulatory hurdles. However, ongoing research, policy support, and technological advancements are expected to drive further innovation and integration into mainstream industrial practices.

Examples of Green Chemistry

Biodiesel Oil

Biodiesel is produced from the seeds of plants like Jatropha curcas through transesterification, where the oil reacts with methanol in the presence of potassium hydroxide. A by-product of this process is glycerine, which is valuable in soap manufacturing. Biodiesel offers several benefits: it is derived from renewable sources, does not release sulfur pollutants, and helps maintain atmospheric carbon dioxide balance since the plants absorb CO? during growth, offsetting emissions from combustion. Supercritical fluids (SCFs) are increasingly being used in chemical reactions to enhance sustainability.

Carbon Dioxide as a Solvent

Carbon dioxide is naturally present in the atmosphere and is also generated from industrial activities like ammonia, hydrogen, and ethanol production, as well as fuel combustion. Instead of being released into the environment, CO? can be captured and repurposed, reducing greenhouse gas emissions and aligning with environmental regulations. As a solvent, CO? is non-toxic and environmentally safe. While it can break down small molecules on its own, commercial applications became viable only after the development of specialized surfactants. Supercritical CO? is particularly useful in dissolving polar solvents like fluorocarbons, acetone, and methanol. One of its earliest applications was in the decaffeination of coffee and tea.

Hydrazine Production (Peroxide Process)

Traditionally, hydrazine was synthesized using the Olin Raschig process, which involves sodium hypochlorite (found in bleach) and ammonia, resulting in the formation of sodium chloride as a by-product:

NaOCl+2NH₃→H₂N-NH₂+NaCl+H₂O

However, a greener alternative is the peroxide process, where hydrogen peroxide acts as the oxidant, and water is the only by-product:

NH₃+H₂O₂→H₂N-NH₂+2H₂O

This method aligns with Principle 4 of Green Chemistry, eliminating the need for additional extraction solvents. Hydrazine is carried by methyl ethyl ketone in an intermediate ketazine phase, simplifying the separation process.

Lactide and Polylactic Acid (PLA) Polymers

Cargill Dow (now NatureWorks) improved the production of polylactic acid (PLA) polymers, which are derived from lactic acid obtained by fermenting grain. These polymers are used in textiles, cutlery, and food packaging. The process involves the catalytic cyclization of lactic acid to form lactide, a cyclic dimer ester. The L,L-lactide enantiomer is then distilled and polymerized in the melt phase to create biodegradable polymers. PLA production replaces petroleum-based feedstocks with renewable resources and eliminates the need for hazardous organic solvents. Major retailers like Wal-Mart have adopted PLA-based packaging.

Application of Green Chemistry in Pharmaceuticals

Naproxen:
Naproxen can be synthesized using a chiral metal catalyst along with the ligand BINAP (2,2'-bis(biphenyl phosphino)-1,1'-binaphthyl). This method allows for high yields with controlled reaction conditions, making it a more environmentally friendly approach.
Ibuprofen:
BASF has developed a greener method for synthesizing ibuprofen, reducing the number of reaction steps by half. This innovation has doubled the atom efficiency compared to earlier processes. Additionally, BASF introduced BASIL™ (Bi-phasic Acid Scavenging Using Ionic Liquids) technology, which aids in the sustainable production of the photocatalyst alkoxyphenylphosphine.
Atorvastatin:

The synthesis of atorvastatin involves biocatalytic reduction using glucose and keto-reductase. Initially, ethyl-4-chloro-3-oxobutanoate undergoes biocatalytic reduction, yielding ethyl-4-chloro-3-hydroxybutyrate with high efficiency. In the next step, halogens are introduced, replacing the chloro group to facilitate the cyano group formation, enhancing the yield and sustainability of the process.

7. Future Trends in Green Chemistry

The future of green chemistry focuses on developing oxidation reagents and catalysts that eliminate the use of toxic heavy metals, which negatively impact human health and the environment. Emerging trends include:

Non-covalent derivatization for improved reaction efficiency.
Supramolecular chemistry to design reactions that proceed in the solid state without the need for solvents.
Biometric multifunctional reagents for sustainable synthesis.
Combinatorial green chemistry, enabling the rapid creation of numerous chemical compounds on a small scale.
Expansion of solvent-less reactions, reducing waste generation and simplifying product isolation and purification.

Key Areas of Green Chemistry Advancement

a) Green Nanochemistry – Using nanotechnology to develop environmentally safe processes.
b) Supramolecular Chemistry – Designing self-assembling molecular systems with reduced toxicity.
c) Combinatorial Green Chemistry – Accelerating compound synthesis while minimizing waste.
d) Eco-friendly Oxidation Reagents & Catalysts – Eliminating toxic substances from industrial processes.
e) Biometric Multifunctional Reagents – Enhancing efficiency and reducing hazardous by-products.

Green Chemistry in the Pharmaceutical Industry

Green chemistry plays a crucial role in the pharmaceutical sector by designing safer chemicals and processes that minimize harm to human health and the environment. It also promotes sustainability in chemical production. Key objectives include:

Developing industrial processes that prevent hazardous risks.
Creating eco-friendly chemicals and materials.
Assessing the environmental and toxicological impact of biomass processing.
Utilizing environmentally safe solvent systems.
Transforming waste into valuable resources.
Reducing the production of toxic by-products.

By adopting green chemistry principles, the pharmaceutical industry can enhance efficiency, reduce pollution, and contribute to sustainable development.

Green Chemistry in Education

Education is the foundation for encouraging chemists to adopt sustainable practices. The concept of teaching Green Chemistry in classrooms was first introduced in 1994. However, Green Chemistry textbooks remain scarce, despite their importance for students, educators, and researchers. These resources play a crucial role in helping future scientists develop environmentally friendly chemical processes while minimizing hazardous substances.

To address this gap, major organizations like the Environmental Protection Agency (EPA) and the American Chemical Society (ACS) have launched initiatives to:

Develop Green Chemistry teaching resources for academic institutions.
Incorporate sustainability principles into chemistry curricula.
Promote research and innovation in eco-friendly chemical practices.

Importance of Student Engagement

The widespread adoption of Green Chemistry principles in both academia and industry depends on student participation. The ACS Student Affiliate Chapters can earn a "Green Chapter" designation by engaging in at least three Green Chemistry activities during the academic year. Some impactful activities include:

Inviting guest speakers to discuss sustainable chemistry innovations.
Organizing campus workshops focused on multidisciplinary Green Chemistry topics.
Partnering with local industries to implement Green Chemistry solutions.
Collaborating with schools to develop hands-on Green Chemistry experiments.
Redesigning traditional lab experiments to reduce waste and improve sustainability.
Hosting a Green Chemistry poster session to showcase student research.
Publishing a Green Chemistry newsletter for awareness and education.
Developing an eco-friendly website to share knowledge and updates.

Impact of Green Chemistry Education

By integrating Green Chemistry into academic programs, students can:

Gain expertise in environmentally responsible chemical design.
Contribute to reducing pollution and hazardous waste.
Develop innovative solutions for a sustainable future.
Enhance career opportunities in green technology and sustainable industries.

Promoting Green Chemistry education ensures that future generations of scientists and industry professionals prioritize sustainability, leading to a safer and greener world.

CONCLUSION

Green chemistry is a transformative approach that prioritizes sustainability, safety, and efficiency in chemical processes. By adhering to its twelve principles, industries can minimize hazardous waste, reduce environmental pollution, and enhance resource utilization. The integration of green solvents, energy-efficient equipment, and eco-friendly raw materials has led to significant advancements in pharmaceuticals, agrochemicals, materials science, and energy production. Despite challenges such as high implementation costs and regulatory hurdles, green chemistry continues to drive innovation and industrial responsibility. The development of biodegradable materials, renewable energy solutions, and environmentally benign synthesis methods showcases its potential to create a sustainable future. As research progresses and industries embrace greener alternatives, green chemistry will play a crucial role in addressing global environmental challenges and fostering a cleaner, safer, and more sustainable world

REFRENCES

Wale T, Suryavanshi S, Wavare V, Sharmale M, Phalke P. Review on Green Chemistry, Journal of Drug Delivery and Therapeutics. 2023;13(7):190-193.
Ahluwalia VK. Green chemistry: Environmentally benign reactions. Green Chem Environ Benign React. 2021;(March):1–354.
Quazi S, A A, Thomas CE. A critical review on the beginning, recent advancement and upcoming challenges of green chemistry. Sch Int J Chem Mater Sci. 2020;3(6):58–64.
Saini RD. Green Chemistry in Daily Life. Int J Res Appl Sci Eng Technol. 2018;6(2):70–3.
Kumar A. Historic development of green chemistry. Chem Educ [Internet]. 2013;18(September):1–4. Available:https://www.researchgate.net/publication/242343420
Anastas PT, Williamson TC. Green Chemistry: An Overview. ACS Symp Ser. 1996;626.
Mukherjee P. Green chemistry -A novel approach towards sustainability. J Chil Chem Soc. 2021;65(1):5075–80.
Clark JH. Clark -Green chemistry Challenges and opportunities. 1999;(February):1–8.
Thorat J. The role of green chemistry and its applications in day-to-day life; 2022(November).
Veeraiah MK. Indian Journal of Advances in Chemical Science Antimicrobial Copolymers of N-vinylpyrrolidone. 2016;(August):52–5.
Factor SI. Chemistry goes green: A review on current and future perspectives of pharmaceutical green chemistry. 2020;6(7):125–31.
Wahid M, Ahmad F, Ahmad N. Green Chemistry: Principle and its application green chemistry: Principle and its Application. Icaeasm-2017. 2017;4(February):120–4.
Raj Joshi D, Adhikari N. Green chemistry: Beginning, recent progress, and future challenges. Dirgha al World J Pharm Pharm Sci [Internet]. 2019;8(July):280. Available:www.wjpps.com
American Chemical Society. Green chemistry history -American Chemical Society [Internet]; 2020. Available:https://www.acs.org/content/acs/en/greenchemistry/what-is-green-chemistry/history-of-green-chemistry.html%0Ahttps://www.acs.org/content/acs/en/greenchemistry.html
Neethu Ann Georgie DNAG. An overview on green logistics. Int J Bus Manag Res. 2019;9(3):69–76.
Parvez S, Kaur P, Sharma R, Sharma N, Pannu S. Green chemistry: Recent advancements and future perspectives. 2023;12(4):14188–97.
Available:https://stock.adobe.com/search?k=%22green+chemistry%22
Adam DH, Elvina, Hasibuan MNS, Syahputra R, Pasaribu LH, Suryani. Green chemistry: The economic impact perspective. Int J Sci Technol Res. 2020;9(4):471–3.
Available:https://themasterchemistry.com/introductoin-to-green-chemistry/#Challenges_in_Green_Chemistry
Review on current approach to design green chemistry.2023;8(1):880–9.
Bhabad VD. Principles, applications and disadvantages of green chemistry review Kadam and Bhangale; J. Pharm. Res. Int., vol. 36, no. 7, pp. 39-50, 2024; Article no.JPRI.11724350 article. J Emerg Technol Innov Res. 2018;5(12):635–42.
Gupta V. Green chemistry: As an Alternative Tool for Reducing Pollution. 2020;9(4):213–22.
Wardencki W, Cury?o J, Namie?nik J. Green chemistry -Current and future issues. Polish J Environ Stud. 2005;14(4):389–95.
Available:https://en.wikipedia.org/wiki/Green_chemistry
Benefits of Green Chemistry | US EPA [Internet]. United States Environmental Protection Agency;2022. Available:https://www.epa.gov/greenchemistry/benefits-green-chemistry
Dhage SD. Applications of green chemistry in everyday life. Int J Res Pharm Chem. 2013;3(3):518–20.
Ivankovi? A. Review of 12 principles of green chemistry in practice. Int J Sustain Green Energy. 2017;6(3):39.
de Marco BA, Rechelo BS, Tótoli EG, Kogawa AC, Salgado HRN. Evolution of green chemistry and its multidimensional impacts: A review. Saudi Pharm J [Internet]. 2019;27(1):1–8. Available:https://doi.org/10.1016/j.jsps.2018.07.011.