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Abstract

Ashokarishta, a renowned Ayurvedic formulation, has been traditionally used to treat gynecological disorders, especially menorrhagia, dysmenorrhea, and leucorrhea. It is a fermented decoction containing the bark of Saraca asoca as its primary ingredient, combined with various herbs and jaggery. This review explores its therapeutic significance, preparation methods, advantages, limitations, and pharmacological evaluations. With growing global interest in herbal remedies, Ashokarishta is being reevaluated for its efficacy in modern clinical settings. This paper aims to provide a comprehensive overview based on traditional texts and modern scientific research [1]..

Keywords

Ashokarishta, gynecological disorders, especially menorrhagia, dysmenorrhea, and leucorrhea.

Introduction

Ayurveda, the conventional Indian pharmaceutical, has given the world a wealthy pharmacopoeia of plant-based drugs. Of these, Ashokarishta is one such female tonic, utilized basically in regenerative and hormonal disorders [2]. The plant ingredient, Saraca asoca, moreover known as the Ashoka tree, is worshiped for its uterotonic and anti-inflammatory activities [3]. Ashokarishta has a place to the "Arishta" gather of Ayurvedic aged drugs, which have more prominent shelf-life and progressed bioavailability [4]. Its persistence in utilize over centuries shows its part in conventional wellbeing frameworks [5].

3. Medical Applications

The preparation is primarily applied to various menstrual disorders. It is a uterine tonic and is specifically effective in treating menorrhagia, or excessive menstrual discharge, by stabilizing hormonal imbalance and toning uterine muscles [6]. Apart from menorrhagia, Ashokarishta is also effective in managing dysmenorrhea (painful menstruation), amenorrhea (absence of menstruation), and leucorrhea (vaginal discharge), and thus is a multi-purpose gynecological drug [7]. Further, it has been found to be effective in women suffering from polycystic ovarian syndrome (PCOS) as it can regulate ovulatory cycles [8].

Several clinical trials have made it effective in relieving uterine bleeding and pelvic pain [9]. It has further been used to treat general debility, anemia, and gastrointestinal disturbances in women, which are prevalent with reproductive disorders [10].

4. Benefits of Ashokarishta

One of the strongest points in favor of Ashokarishta is that it is of herbal origin, thus minimizing the potential for side effects of chemical medicines [11]. Unlike most allopathic medicines for menstrual complaints, Ashokarishta can be taken over a long period of time under medical supervision [12]. Its multi-herbal nature provides an integrated therapeutic approach, not just suppressing symptoms but also harmonizing systemic imbalances [13]. The alcohol produced endogenously by the process of fermentation helps in the absorption of active principles, thus enhancing its pharmacological action [14].

In addition, it is relatively cheap, easy to store, and readily available in Indian urban and rural settings [15]. These features make it a popular choice in resource-poor settings where access to modern health care is still limited [16].

5.DISADVANTAGE

Whereas it is useful ashokarishta has a few demerits as a matured medicate its alcohol substance in spite of the fact that insignificant can demonstrate problematic with certain bunches of people such as children pregnant ladies or those with liquor narrow mindedness [17]. furthermore contrasts in the quality of herbs utilized and planning strategies can cause contrasts in restorative results [18 ].need of appropriate standardization and quality control in the larger part of commercial arrangements has the potential to influence their adequacy and security [19]. further logical confirmation in the shape of large-scale randomized clinical trials is missing hence not accomplishing common adequacy in evidence-based standard medication [20].potential herb-drug intelligent when taken concurrently with standard drugs too require caution[21].

6. Arrangement Procedure

Preparation of Ashokarishta, a classical Ayurvedic sedate, is too conventional and incorporates cautious choice, bubbling, maturation, and capacity of the restorative plants. The taking after is a detailed step-by-step depiction of the customary strategy embraced in the arrangement of this home grown drug:

Step 1: Component Choice and RefiningThe most imperative plant utilized is the bark of Ashoka tree (Saraca asoca), which is exceedingly esteemed for its therapeutic esteem. Other than Ashoka bark, other plant substances are included to the arrangement, such as Dhataki (Woodfordia fruticosa), Haritaki (Terminalia chebula), Amalaki (Emblica officinalis), and numerous others, depending on the person classical definition being taken after [22].

 #All the fixings are cleaned completely to evacuate any soil and impurities.

Step 2: Arrangement of the Decoction (Kashayam)

The Ashoka bark, together with other powdered home grown fixings, is bubbled in a measured sum of water to make a decoction. This is done by stewing the blend over a moo warm until the fluid is diminished to approximately one-fourth of its unique volume. This is done to guarantee the extraction of dynamic compounds from the herbs [23].

Step 3: Filtration of the Decoction

After the decoction has come to the wanted quality, the decoction is tolerably cooled and at that point passed through a sterile muslin cloth or a sifter in arrange to expel the strong particles. The clear home grown extricate so gotten is the base of the aging handle [23].

Step 4: Expansion of Sweetener (Guda)

In the sifted decoction, jaggery, a unrefined cane sugar known as guda, is included in a particular amount. Jaggery not as it were acts as a sweetener but is moreover a fermentable sugar which is required amid the handle of aging [23].

Step 5: Start of Aging utilizing Dhataki Flowers

With the total disintegration of jaggery, Dhataki blooms (Woodfordia fruticosa) are included to the blend. The blossoms normally carry yeast and cause aging by changing over sugars into negligible sums of liquor. The expansion of these blooms is basic since they act as characteristic aging specialists, in this way empowering a self-generating and chemical-free handle of maturation [24].

Step 6: Maturation Process

The pre-mixed mix is exchanged to a clean, dry, and sterilized aging vessel—historically of pottery or glass. The vessel is closed and cleared out undisturbed in a warm put at room temperature, ordinarily between 25°C and 35°C. Aging takes 15 to 30 days when normal microbial activity changes over the mix to a pitifully alcoholic home-grown mixture [25].

Step 7: Post-Fermentation Filtration After the aging handle is completed, the fluid is subjected to another filtration to expel any remaining silt or home grown buildups. This prepare is required for guaranteeing the virtue and clarity of the last item [25]. Step 8: Bottling and Conservation The straightforward, aged liquid is at that point filled into air-tight glass holders and kept in a cold, dry area. The coming about item is Ashokarishta—a sweet, somewhat inebriating arrangement with strongly reddish-brown color and fabulous restorative potential [26].  This conventional strategy guarantees the conservation and reinforcing of the therapeutic substance of Ashoka and the back herbs by normal maturation. The conclusion item is esteemed for its viability in treating gynecological afflictions and common regenerative wellbeing.

7. Evaluation and Pharmacological Aspects

Understanding the therapeutic value of Ashokarishta requires both traditional knowledge and modern scientific evaluation. In recent years, researchers have begun analyzing this formulation through the lens of pharmacology and analytical chemistry. Here’s a step-by-step overview of its evaluation and pharmacological profile:

Step 1: Identification of Bioactive Compounds

Scientific investigations into Ashokarishta have revealed the presence of several biologically active compounds, particularly derived from Saraca asoca, the main ingredient. These include flavonoids, tannins, and phytoestrogens, which are believed to contribute to the formulation’s therapeutic effects [27].

Step 2: Pharmacological Activities

The compounds found in Ashokarishta exhibit multiple pharmacological actions. Among the most notable are its anti-inflammatory, pain-relieving (analgesic), and estrogen-like effects, all of which align with its traditional use in treating various gynecological disorders such as irregular menstruation, menorrhagia, and uterine discomfort [28].

Step 3: Validation Through Preclinical Studies

Animal-based studies have provided supportive evidence for Ashokarishta’s actions. For instance, its uterine stimulant activity has been confirmed in laboratory models, thereby validating its historical use in managing menstrual irregularities and toning the female reproductive system [29].

Step 4: Broader Therapeutic Potential

Beyond its gynecological applications, Ashokarishta has shown promise in other areas of health as well. Research points to its hepatoprotective (liver-protecting), antioxidant, and anti-stress properties, which make it a holistic remedy in traditional Ayurvedic medicine [30].

Step 5: Analytical Evaluation and Standardization

Modern tools like High-Performance Liquid Chromatography (HPLC) and Gas Chromatography-Mass Spectrometry (GC-MS) have been employed to study the formulation at the chemical level. These techniques help identify and quantify the phytochemicals present, paving the way for partial standardization and quality control of Ashokarishta preparations [31].

Step 6: Challenges in Consistency and Quality

Despite these advancements, a major concern remains: variation in raw materials and preparation techniques across different manufacturers. This inconsistency can affect the potency, efficacy, and safety of the final product, making evaluation more difficult [32].

Step 7: Regulatory and Standardization Efforts

To ensure product consistency and therapeutic reliability, steps are being taken to create monographs and establish pharmacopoeia standards for classical Ayurvedic formulations, including Ashokarishta. These documents aim to define acceptable raw material quality, preparation methods, and chemical markers to guide manufacturers and researchers alike [33].

8. CONCLUSION

Ashokarishta remains a time-tested Ayurvedic formulation with significant therapeutic benefits in female reproductive health. Its natural origin, combined with a broad spectrum of actions, makes it a valuable option in both traditional and integrative medicine frameworks. However, its mainstream adoption will depend on further scientific validation, standardization, and clinical documentation. With appropriate research and quality control, Ashokarishta holds promise as a safe and effective remedy for menstrual and hormonal disorders in women [34].

REFERENCES

  1. Sharma PV. Dravyaguna Vijnana. Chaukhambha Bharati Academy, 2011.
  2. Dash V, Juni RK. Ashokarishta in Ayurveda: A review. J Ayurveda Integr Med Sci. 2020;5(3):102-107.
  3. Nadkarni KM. Indian Materia Medica, Vol 1. Bombay Popular Prakashan, 2002.
  4. Govind Das. Bhaisajya Ratnavali. Chaukhambha Sanskrit Sansthan, 2007.
  5. Acharya YT. Charaka Samhita. Chaukhambha Surbharati, 2005.
  6. Tripathi B. Ashtanga Hridayam. Chaukhambha Sanskrit Pratishthan, 2014.
  7. Bhalerao S, et al. Clinical evaluation of Ashokarishta in menorrhagia. AYU. 2012;33(2):289-292.
  8. Deshpande S. Role of Ashokarishta in PCOS management. J Ayurveda Case Rep. 2021;4(1):15-20.
  9. Tiwari N, et al. Comparative study on Ashokarishta and hormonal therapy. Int J Res Ayurveda Pharm. 2017;8(4):72-76.
  10. Singh R, et al. A review on therapeutic potential of Ashokarishta. Int J Ayurveda Pharm Chem. 2020;13(1):14-20.
  11. Agarwal A. Natural vs synthetic treatments in gynecology. Herbal Med J. 2018;6(2):88-93.
  12. Nariya MB, et al. Safety profile of Ashokarishta. Ayu. 2015;36(1):80-85.
  13. Kumar A, et al. Ayurvedic formulations in reproductive health. J Ayurveda Med Sci. 2019;2(3):43-50.
  14. Saxena P, et al. Fermentation in Ayurveda. Int J Ayurveda. 2020;7(2):55-60.
  15. Choudhury D, et al. Cost analysis of Ayurvedic medicines. J Health Econ. 2019;11(4):23-29.
  16. Basak S. Accessibility of Ayurvedic medicines in India. Indian J Tradit Knowl. 2020;19(1):142-147.
  17. Bhargava S. Alcohol content in Ayurvedic preparations. J Ayurveda Case Rep. 2021;5(2):60-64.
  18. Kumar M, et al. Variability in herbal medicine efficacy. Pharmacogn Rev. 2017;11(21):22-28.
  19. WHO. Guidelines on quality control of herbal medicines. Geneva: World Health Organization; 2018.
  20. Mehta R, et al. Limitations of Ayurvedic trials. Evid Based Complement Alternat Med. 2019;8(4):303-308.
  21. Rao M, et al. Herb-drug interactions in Ayurveda. Int J Integr Med. 2020;3(1):31-36.
  22. Sharma A. Traditional preparation of Arishta. Pharmacogn J. 2018;10(5):1020-1026.
  23. Joshi V. Role of jaggery in Ayurvedic medicine. J Ayurveda Health Sci. 2021;9(2):89-93.
  24. Verma S. Yeast role in fermentation. Ferment Technol. 2019;3(3):1-4.
  25. Goyal M. Preparation of Ashokarishta. J Ayurveda Case Rep. 2019;2(3):55-58.
  26. Dubey N. Fermentation in Ayurvedic decoctions. J Indian Med Assoc. 2020;118(9):22-26.
  27. Pathak S, et al. Phytochemical profile of Saraca asoca. Pharmacogn J. 2017;9(1):23-27.
  28. Kulkarni R, et al. Pharmacological properties of Ashoka bark. J Ayurveda Integr Med. 2019;10(3):198-204.
  29. Desai P. Uterotonic effects of Ashokarishta. Indian J Pharmacol. 2020;52(6):500-504.
  30. Sinha D, et al. Antioxidant potential of Ashokarishta. J Ayurveda. 2020;5(4):33-39.
  31. Rajput V. HPLC fingerprinting of Ayurvedic formulations. J Chromatogr Sci. 2018;56(4):312-317.
  32. Prakash V. Quality control in Ayurvedic pharma. Pharm Tech Today. 2021;7(1):11-15.
  33. AYUSH Ministry. Pharmacopoeial standards of Ayurvedic drugs. Govt of India, 2022.
  34. Sen R. Integrative approach to women’s health. Complement Ther Med. 2021;56:102601.

Reference

  1. Sharma PV. Dravyaguna Vijnana. Chaukhambha Bharati Academy, 2011.
  2. Dash V, Juni RK. Ashokarishta in Ayurveda: A review. J Ayurveda Integr Med Sci. 2020;5(3):102-107.
  3. Nadkarni KM. Indian Materia Medica, Vol 1. Bombay Popular Prakashan, 2002.
  4. Govind Das. Bhaisajya Ratnavali. Chaukhambha Sanskrit Sansthan, 2007.
  5. Acharya YT. Charaka Samhita. Chaukhambha Surbharati, 2005.
  6. Tripathi B. Ashtanga Hridayam. Chaukhambha Sanskrit Pratishthan, 2014.
  7. Bhalerao S, et al. Clinical evaluation of Ashokarishta in menorrhagia. AYU. 2012;33(2):289-292.
  8. Deshpande S. Role of Ashokarishta in PCOS management. J Ayurveda Case Rep. 2021;4(1):15-20.
  9. Tiwari N, et al. Comparative study on Ashokarishta and hormonal therapy. Int J Res Ayurveda Pharm. 2017;8(4):72-76.
  10. Singh R, et al. A review on therapeutic potential of Ashokarishta. Int J Ayurveda Pharm Chem. 2020;13(1):14-20.
  11. Agarwal A. Natural vs synthetic treatments in gynecology. Herbal Med J. 2018;6(2):88-93.
  12. Nariya MB, et al. Safety profile of Ashokarishta. Ayu. 2015;36(1):80-85.
  13. Kumar A, et al. Ayurvedic formulations in reproductive health. J Ayurveda Med Sci. 2019;2(3):43-50.
  14. Saxena P, et al. Fermentation in Ayurveda. Int J Ayurveda. 2020;7(2):55-60.
  15. Choudhury D, et al. Cost analysis of Ayurvedic medicines. J Health Econ. 2019;11(4):23-29.
  16. Basak S. Accessibility of Ayurvedic medicines in India. Indian J Tradit Knowl. 2020;19(1):142-147.
  17. Bhargava S. Alcohol content in Ayurvedic preparations. J Ayurveda Case Rep. 2021;5(2):60-64.
  18. Kumar M, et al. Variability in herbal medicine efficacy. Pharmacogn Rev. 2017;11(21):22-28.
  19. WHO. Guidelines on quality control of herbal medicines. Geneva: World Health Organization; 2018.
  20. Mehta R, et al. Limitations of Ayurvedic trials. Evid Based Complement Alternat Med. 2019;8(4):303-308.
  21. Rao M, et al. Herb-drug interactions in Ayurveda. Int J Integr Med. 2020;3(1):31-36.
  22. Sharma A. Traditional preparation of Arishta. Pharmacogn J. 2018;10(5):1020-1026.
  23. Joshi V. Role of jaggery in Ayurvedic medicine. J Ayurveda Health Sci. 2021;9(2):89-93.
  24. Verma S. Yeast role in fermentation. Ferment Technol. 2019;3(3):1-4.
  25. Goyal M. Preparation of Ashokarishta. J Ayurveda Case Rep. 2019;2(3):55-58.
  26. Dubey N. Fermentation in Ayurvedic decoctions. J Indian Med Assoc. 2020;118(9):22-26.
  27. Pathak S, et al. Phytochemical profile of Saraca asoca. Pharmacogn J. 2017;9(1):23-27.
  28. Kulkarni R, et al. Pharmacological properties of Ashoka bark. J Ayurveda Integr Med. 2019;10(3):198-204.
  29. Desai P. Uterotonic effects of Ashokarishta. Indian J Pharmacol. 2020;52(6):500-504.
  30. Sinha D, et al. Antioxidant potential of Ashokarishta. J Ayurveda. 2020;5(4):33-39.
  31. Rajput V. HPLC fingerprinting of Ayurvedic formulations. J Chromatogr Sci. 2018;56(4):312-317.
  32. Prakash V. Quality control in Ayurvedic pharma. Pharm Tech Today. 2021;7(1):11-15.
  33. AYUSH Ministry. Pharmacopoeial standards of Ayurvedic drugs. Govt of India, 2022.
  34. Sen R. Integrative approach to women’s health. Complement Ther Med. 2021;56:102601.

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Dikisha Singh
Corresponding author

Aakash Institute Of Medical Sciences, Nalagarh.

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Priyanka Devi
Co-author

Aakash institute of medical sciences, Nalagarh.

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Amit kumar
Co-author

Aakash institute of medical sciences, Nalagarh.

Dikisha Singh*, Priyanka Devi, Amit Kumar, A Reviwe Article on Ashokarishta, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 5, 1154-1158 https://doi.org/10.5281/zenodo.15356229

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