Abstract
Indapamide is a Thiazide- suchlike diuretic medicine used in the treatment of hypertension Since 1977. Class of Thiazide- Suchlike diuretics. It shows great capability to overcome Hypertension as well as Heart failure. Different analytical method used to get to determine a chemical or physical property of a chemical substance, chemical element, or mixture. Even though Indapamide has had the approval for clinical use for more than 30 years now most of the analytical methods for its determination reported in the scientific literature are the ones which utilize different analytical methods. This shows which method and which Solvents are more efficient to determine Indapamide.
Keywords
Indapamide, Hypertension, Thiazide,Diuretic, Analytical Method
Introduction
History of Drug[1-3]
- Indapamide is a thiazide- suchlike diuretic medicine used in the treatment of hypertension, as well as decompensated heart failure. Combination medications with perindopril (an ACE asset antihypertensive) are available. The thiazide- suchlike diuretics (indapamide and chlorthalidone) reduce threat of major cardiovascular events and heart failure in hypertensive cases compared with hydrochlorothiazide with a similar prevalence of adverse events. It was patented in 1968 and approved for medical use in 1977.It is on the World Health Organization's List of Essential Medicines.
- It’s Mainly included hypertension and edema due to congestive heart failure. Indapamide has been shown to reduce stroke rates in people with high blood pressure. Studies have shown that the blood pressure lowering goods of indapamide in combination with perindopril reduce the rate of stroke in high threat cases (those with a history of high blood pressure, stroke or type two diabetes). HYVET study showed that indapamide (sustained release), with or without perindopril as antihypertensive treatment in persons 80 times of age or aged with sustained systolic blood pressure of 160 mmHg or advanced, demonstrated significant reduction in all- cause mortality when treated to a target of 150/80 mmHg, but there was set up to be no significant reduction in threat of death from cardiac causes
- Two methodical reviews linked that indapamide with or without perindopril significantly reduced each- beget mortality in youthful- senior cases with a history of stroke, cardiovascular complaint and type 2 diabetes mellitus, when lesser reductions in mean office blood pressure are achieved, significant cardiovascular benefit was only observed when trials including the >75 times old cohort was included.
Class of Drug [4]
Classified as a sulfonamide diuretic, indapamide is an effective antihypertensive agent and by extension, has shown efficacity in the forestallment of target organ damage. Administration of indapamide produces water and electrolyte loss, with advanced boluses associated with increased diuresis. Drug Profile of Indapamide.
Table 1 Drug Profile of Indapamide
Current Research on Indapamide-
Current exploration on Indapamide- Indapamide (IND) is a medic action to treat high blood pressure that can reduce oxidative stress and ameliorate the survival of whim-whams cells in laboratory studies. IND is presently approved to treat high blood pressure. IND is available in tablet form and is generally taken formerly a day, the most typical cure is 2.5 mg. It's estimated that a cure of 2.5 mg per day will be sufficient to treat oxidative stress in SPMS. IND is generally well permitted.
REVIEW OF LITERATURE
Table 2 UV spectrophotometric method of Indapamide
Table 3 HPLC Method of Indapamide
Table 4 HPTLC Method of Indapamide
Table 5 LC-MS method of indapamide
Different pie Chart Acoording to Methods and solvents .
Fig-1 Methos Found for Indapamide
Fig 2- Solvent Used for Indapamide
CONCLUSION
Indapamide is one of the most important Thiazides and even though it received approval for clinical use in the year 1977, just a few analogs of Indapamide have been able to reach the stages of clinical development. The HPLC-based methods coupled with UV are the major analytical techniques available in the literature for the determination of Indapamide in pharmaceuticals as well as in the Development Stages. Most of the methods included in the present review have used HPLC systems coupled with UV detectors. The analytical methods that use mass spectrometers as detectors have emerged in recent years as well as high amount. After the Literature review, we found most of the methods used Methanol and Phosphate Buffer in different ranges.
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10.5281/zenodo.13629931
