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  • Review On Resealed Erythrocytes As A Novel Drug Delivery System
  • Department Of Pharmaceutics, LBYP College Of Pharmacy, Pathri, Aurangabad, Maharashtra, India

Abstract

A new strategy that combines inventive development, formulation, new technology, and novel methodology for delivering pharmaceutical compounds in the body as needed to successfully achieve their targeted pharmacological effect is known as a novel drug delivery system. There are numerous novel drug delivery systems available. Among them, "drug- loaded erythrocytes" are one of the most expanding and prospective systems for the delivery of medications and enzymes. Erythrocytes are natural components that make them suitable for use as drug delivery systems to enhance the pharmacokinetics, bioavailability, and many other properties of several medications. Erythrocytes are highly beneficial for targeted and controlled drug delivery systems. Erythrocytes are biocompatible, biodegradable, have a long circulation half-life, and can be loaded with a range of biologically active substances. The aim of the present review is to focus on various features, composition, advantages, disadvantages, isolation, drug loading methods, storage, route of administration, evaluation, application, and novel approaches, future perspectives to resealed erythrocytes.

Keywords

Resealed erythrocytes, Drug targeting, Isolation, Drug loading method, Carrier erythrocytes

Reference

  1. Mao, Y., Zou, C., Jiang, Y., & Fu, D. (2021). Erythrocyte-derived drug delivery systems in cancer therapy.Chinese Chemical Letters, 32(3), 990-998.https://doi.org/10.1016/j.cclet.2020.08.048
  2. Banskota, S., Yousefpour, P., & Chilkoti, A. (2017). Cell?based biohybrid drug delivery systems: The best of the synthetic and natural worlds. Macromolecular Bioscience, 17(1), 1600361.
  3. Ihler, G. M., Glew, R. H., & Schnure, F. W. (1973). Enzyme loading of erythrocytes. Proceedings of the National Academy of Sciences, 70(9), 2663-2666.
  4. Khandbahale, S. V., & Saudagar, R. B. (2016). Review on Resealed Erythrocyte. Asian Journal of Research in Pharmaceutical Science, 6(4), 261-268.https://doi.org/10.5958/2231- 5659.2016.00037.0
  5. Kavitake, P. A., GD, M. T., Tikute, N. D., Talmohite, A. M., & Lokhande, V. Y. Resealed Erythrocyte as a Drug Carrier.
  6. Sahdev, A. K., & Sethi, B. (2019). Important Role, Isolation and Basic Concept of Resealed Erythrocytes. Research Journal of Pharmacy and Technology, 12(5), 2603-2611.
  7. Gothoskar, A. V. (2004). Resealed erythrocytes: a review. Pharmaceutical Technology, 28(3), 140-155.
  8. Krishnaveni, G., Krishnamoorthy, B., & Muthukumaran, M. (2013). Future Prospectus in Targetting Drug Delivery: A Review on Resealed Erytrocytes-A Promising Carrier. Schol. Acad. J. Pharm, 2, 81-88.
  9. Giri, S., & Bose, S. (2017). Resealed Erythrocyte: An Updated Engineering and Novel Approach for Targeted Drug Delivery. Journal of PharmaSciTech.
  10. Deepika, B. R., Ram, S. S., Ketan, K. D., & Halle, P. D. (2013). Resealed erythrocytes drug delivery: A review. Int J Res Pharm Chem, 3(2), 198-207.
  11. Kumari, R., Panda, P., Singh, R., Vishwakarma, D., Mishra, J., & Verma, N. K. (2018). Resealed Erythrocyte: An Approach to Targeted Drug Delivery. Chem. J, 1, 1-11. http://purkh.com/index.php/tochem
  12. Jain, N. K. (Ed.). (1997). Controlled and novel drug delivery (pp. 236-237). New Delhi: CBS publishers & distributors.
  13. Shah, S. (2011). Novel drug delivery carrier: resealed erythrocytes. International Journal of Pharma and Bio Sciences, 2(1), 394-406.
  14. Gupta, R. (2014). Resealed erythrocytes: carrier for smart drug delivery. World J. Pharmaceut. Res., 3, 1722-1747.
  15. Sah, A. K., Rambhade, A., Ram, A., & Jain, S. K. (2011). Resealed erythrocytes: A Novel carrier for drug targeting. Journal of Chemical and Pharmaceutical Research, 3(2), 550-565.
  16. Pragya, R. V. (2012). Resealed erythrocytes: a promising drug carrier. International Journal of Pharmacy and Pharmaceutical Sciences, 4(3).
  17. Brahmankar, D. M., & Jaiswal, S. B. (2019). Biopharmaceutics and pharmacokinetics. Vallabh prakashan.
  18. Kumar, A., Verma, M., & Jha, K. K. (2012). Resealed Erythrocytes as a Carrier for Drug Targeting: A Review. The pharma innovation, 1(2, Part A), 8.
  19. Rao, T., Prabha, S., & Prasanna, M. (2011). Resealed Erythrocytes : As a Specified tool in Novel Drug Delivery Carrier System496-512.
  20. Bellad, K. A., Nanjwade, B. K., Kamble, M. S., & Srichana, T. (2017). Resealed erythrocytes based drug delivery system. World journal of pharmacy and pharmaceutical sciences, 6, 2-446.
  21. Alli, P. R., Kulat, R. B., & Bhagat, B. V. (2016). Resealed erythrocytes: A novel drug delivery system. Asian J Pharm Technol Innov, 4, 119-30.
  22. Vats, V. (2020). Novel drug delivery system: Resealed Erythrocytes. Turkish Journal of Computer and Mathematics Education (TURCOMAT), 11(2), 706-719.
  23. Hirlekar, R. S., Patel, P. D., Dand, N., & Kadam, V. J. (2008). Drug loaded erythrocytes: as novel drug delivery system. Current pharmaceutical design, 14(1), 63-70.
  24. Talwar, N., & Jain, N. K. (1992). Erythrocytes as carriers of primaquine-preparation: characterization and evaluation. Journal of controlled release, 20(2), 133-141..
  25. Garin MI, Lopez RM, Sanz S, Pinilla M and Luque J; Erythrocytes as Carriers for Recombinant Human Erythropoietin, Pharm. Res., 1996, 13: 869–874
  26. Jain, S., Jain, S. K., & Dixit, V. K. (1995). Erythrocytes based delivery of isoniazid: preparation and in-vitro characterization. Indian Drugs, 32(10), 471-476.
  27. Hamidi, M., Tajerzadeh, H., Dehpour, A. R., Rouini, M. R., & Ejtemaee-Mehr, S. (2001). In vitro characterization of human intact erythrocytes loaded by enalaprilat. Drug Delivery, 8(4), 223-230.
  28. Updike, S. J., & Wakamiya, R. T. (1983). Infusion of red blood cell-loaded asparaginase in monkey: Immunologic, metabolic, and toxicologic consequences. The Journal of laboratory and clinical medicine, 101(5), 679-691.
  29. Cannon, E. P., Leung, P., Hawkins, A., Petrikovics, I., DeLoach, J., & Way, J. L. (1994). Antagonism of cyanide intoxication with murine carrier erythrocytes containing bovine rhodanese and sodium thiosulfate. Journal of Toxicology and Environmental Health, Part A Current Issues, 41(3), 267-274.
  30. Cuppoletti, J., Mayhew, E., Zobel, C. R., & Jung, C. Y. (1981). Erythrosomes: large proteoliposomes derived from crosslinked human erythrocyte cytoskeletons and exogenous lipid. Proceedings of the National Academy of Sciences, 78(5), 2786-2790.
  31. Jung, C. Y. (1987). [20] Erythrosomes: Erythrocyte cytoskeletons coated with exogenous phospholipid as an encapsulating system. In Methods in Enzymology (Vol. 149, pp. 217- 221). Academic Press.
  32. Singh, S. K., Yadav, S. K., Kumar, A., & Dutta, A. S. (2013). Mechanism of drug loading, evaluation and applications of erythrocytes as carriers for drug targetting. Indian Journal of Research in Pharmacy and Biotechnology, 1(1), 67.
  33. Moorjani, M. I. R. A., Lejeune, A., Gicquaud, C. L. A. U. D. E., Lacroix, J. A. C. Q. U.E. S., Poyet, P. A. T. R. I. C. K., & Gaudreault, R. C. (1996). Nanoerythrosomes, a ne derivative of erythrocyte ghost II: identification of the mechanism of action. Anticancer research, 16(5), 2831-2836
  34. EUNE, A. L., PoVET, P. A. T. R. I. C. K., C-GAUDREAULT, R. E. N. E., & GICOUAUD, C. (1997). Nanoerythrosomes, a new derivative of erythrocyte ghost: III. Is phagocytosis involved in the mechanism of action?. Anticancer research, 17, 3599-3604.
  35. Gill, R. (2012). Resealed erythrocytes as a potential drug carrier system. International Journal of Pharmaceutical Sciences and Research, 3(2), 383.

Photo
Pallavi Ambadas Dandge
Corresponding author

Late Bhagirathi Yashwantrao Pathrikar college of d pharmacy Pathri, Aurangabad.

Pallavi Ambadas Dandge*, Ms. Pranali Hatwar, Gajanan Sanap, Review On Resealed Erythrocytes As A Novel Drug Delivery System, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 108-120. https://doi.org/10.5281/zenodo.10259634

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