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  • Innovations In Fast Disintegrating Tablet Formulation Harnessing The Power Of Super Disintegrants For Rapid Oral Dissolution A Review
  • 1,2,3,5 Department of pharmaceutics, Sarada Villas College of Pharmacy, Mysuru, Karnataka, India 
    4 Department of Pharmacognosy, Sarada Villas College of Pharmacy, Mysuru, Karnataka, India
     

Abstract

This work looks into how to improve the oral dissolving qualities of fast disintegrating tablets (FDTs) by formulating and testing them using cutting-edge super disintegrants. Modern super disintegrants have the ability to dissolve and disintegrate quickly in FDTs, which could be advantageous for patient convenience and compliance. To maximize tablet disintegration times, a variety of super disintegrants were used, such as sodium starch glycolate, crospovidone, and croscarmellose sodium. Excipients such binders, diluents, and sweeteners were carefully chosen to ensure compatibility and maintain the overall integrity of the tablet matrix. Hardness, friability, and disintegration time—three physicochemical characteristics of FDTs—were methodically assessed in order to determine how various super disintegrants affected the quality of the tablets. To evaluate the drug release characteristics of FDTs, in vitro dissolution assays were carried out utilizing recognized dissolution media. When the results were compared to those of conventional tablets, the dissolution kinetics showed the enhanced performance ascribed to the addition of super disintegrants. Evaluations of stability under both fast and extended storage settings were carried out to guarantee the long-term resilience of the developed FDTs. A thorough examination looked into how the environment might affect the tablets' chemical and physical stability.

Keywords

Super disintegrants, Fast disintegrating Tablets, Microcrystalline cellulose, sodium croscarmellose, sodium starch glycolate.

Reference

  1. Shaikh S, Khirsagar RV, Quazi A. Fast Disintegrating Tablets: An Overview Of Formulation And Technology. Int J Pharm Pharm Sci. 2010; 2(3):9-15.
  2. Deshpande KB, Ganesh NS. Orodispersible Tablets: An overview of formulation and technology. Int J Pharm Bio Sci. 2011;2:726-73.
  3. Gupta DK, Bajpai M, Chatterjee DP. Fast mouth is dissolving disintegrating tablet and patient counselling points for FDDTS-a review. Int J Res Dev Pharm L Sci. 2014;3:949-58.
  4. Kumar Dinesh V, Sharma IR, Sharma V. A Comprehensive review on fast dissolving tablet technology. J Appl Pham Sci. 2011;1(05):50-8.
  5. Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving films: an innovative drug delivery system and dosage form. Int J Chem Tech. 2010;4:576-83.
  6. Bhyan B, Jangra S, Kaur M, Singh H. Orally Fast Dissolving Films: Innovations in Formulation and Technology. Int J Pharm Sci. 2011; 9(2):50-57.
  7. Patil SL, Mahaparale PR, Shivnikar MA, Tiwari SS, Pawar KV, Sane PN. Fast dissolving oral films: an innovative drug delivery system. Int J Res Rev Pharm Appl Sci. 2012;2(3): 482-96.
  8. Patil PC, Shrivastava SK, Vaidehi S, Ashwini P. Oral fast dissolving drug delivery system: a modern approach for patient compliance. Int J Drug Regul Aff. 2014;2(2):49–60.
  9. Hirani JJ, Rathod DA, Vadalia KR. Orally Disintegrating Tablets: A Review. J Pharm Res. 2009;8(2):161- 72. 17. Hannan PA, Khan JA, Khan A, Safiullah S. Oral dispersible system: A new approach in drug delivery system. Ind J Pharm Sci. 2016;7(8):2-7.
  10. Kundu S, Sahoo PK. Recent Trends In The Developments of Orally Disintegrating Tablet Technology. Pharm Times. 2008;40(4):11-15
  11. Erande, K, Joshi, B. Mouth Dissolving Tablet: A comprehensive Review, Int J Pharm Res Rev. 2013;2(7):26-28.
  12. Chaudhari, PD, Chaudhari SP, Lanke SD, Patel N.Formulation and in vitro evaluation of taste masked orodispersible dosage form of Levocetirizine dihydrochloride. Ind J Pharm Edu Res. 2007;41(4):319-27.
  13. Belet MH and Derle DV: Analysis of patents pertaining to superdisintegrants used in tablet manufacturing. Journal of intellectual Property Rights 2008; 13: 601-604.
  14. Omidian H and Park K: Swelling agents and devices in oral drug delivery. Journal of Drug Delivery Science and Technology 2008; 18 (2): 83-93.
  15. Iyad R, Mayyas AR, Eftaiha AA and Badwan A: Chitin-silicon dioxide coprecipitate as a novel superdisintegrant. Journal of Pharmaceutical Sciences 2008; 97(11): 4955-69.
  16. Kumaran AK, Sreekanth J and Palanisamy S: Formulation, development and evaluation of Levodopa-Carbidopa orally disintegration tablets. Journal of Chemical and Pharmaceutical Research 2011; 3(3): 169-175.
  17. Uddhav S Bagul. (2006). Current status of tablet disintegrants: a review. Retrieved March 5, 2011 from Pharmainfo.net. http://www.pharmainfo.net/reviews/current-status-tabletdisintegrantsa-review.
  18. Raymond CR: Handbook of Pharmaceutical Excipients. APhA Publishers, Fifth Edition 2006.
  19. Polyplasdone superdisintegrants product overview. ISP Pharmaceuticals. April 11, 2011. < http>.
  20. Goel H, Rai P, Rana V and Tiwary AK: Orally disintegrating systems: innovations in formulation and technology. Recent Patents on Drug Delivery & Formulation 2008; 2: 258-274.
  21. Camarco W, Ray D and Druffner A: Selecting superdisintegrants for orally disintegrating tablet formulations. Pharmaceutical Technology Supplement 2006.
  22. Superdisintegrants: an introduction to chemistry and performance. April 12, 2011.
  23. Newman AW, Mueller RL, Vitez IM and Kiesnowski CC: Starch and starch derivatives. Encycolpedia of Pharmaceutical Technology, Informa Healthcare USA 2007.
  24. GK Bolhuis, AW Arends-Scholte, GJ Stuut and JA de Vries: Disintegration efficiency of sodium starch glycolates prepared from different native starches. European Jounal of Pharmaceutics and Biopharmaceutics 1994; 40(5): 317 – 320.
  25. Patel SS, Patel MS, Patel NM. Flowability testing of directly compressible excipients according to British pharmacopoeia. J Pharm Res 2009;8: 66 -9.
  26. Deshmukh VN. Mouth Dissolving Drug Delivery System: A Review. Int J Pharm Tech Res. 2012;4(1):412- 21.
  27. Patel ST, Sengupta M. Fast Dissolving Tablet Technology – A Review. World J Pharm Pharm Sci. 2013;2(2):485-508.
  28. Singh J, Walai M, Harikumar SL. Formulation and evaluation of fast dissolving tablets of Rosuvastatin. J Drug Deliv Ther. 2014;4(5):173-81.
  29. Masareddy RS, Kadia RV, Manvim FV. Development of mouth dissolving tablet of clozapine using two different techniques, In J Pharm Sci. 2008;5:526-28.
  30. Lalla JK, Mamania HM. Fast dissolving of rofecoxib tablets. Ind J Pharm Sci 2004; 59(4):23-26. www.ijppr.humanjournals.com Citation: NAFID ANSARI et al. Ijppr.Human, 2020; Vol. 18 (3): 689-712. 712
  31. Hindustan AA, Chitta SK, Kishore K, Reddy B, Kumar AB, Sekhar CA et al. A Novel Technique in Formulation and Evaluation of Mouth Dissolving Nimesulide Tablets. J Adv Pharm Res 2010;1(2):101-07.
  32. Kumar S, Gupta SK, Sharma PK. A review on recent trends in oral drug delivery- fast dissolving formulation technology. Adv Bio Sci 2012;6 (1):06-13.

Photo
Anusha B.H.
Corresponding author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India

Photo
Nagendra R.
Co-author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India

Photo
Venkatesh K.
Co-author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India

Photo
Hanumanthachar Joshi
Co-author

Department of Pharmacognosy, Sarada Villas College of Pharmacy, Mysuru,Karnataka,India

Photo
Tanuja A . J.
Co-author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy Mysuru, Karnataka, India

Nagendra R. , Anusha B. H. , Venkatesh K., Hanumanthachar Joshi, Tanuja A. J., Innovations In Fast Disintegrating Tablet Formulation: Harnessing The Power Of Super Disintegrants For Rapid Oral Dissolution- A Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 380-391. https://doi.org/10.5281/zenodo.10673308

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