View Article

  • From Roots To Remedies A Review Of Commiphora Opobalsamum Plant Features, Phytochemistry, Pharmacological Insights And Safety
  • 1Research Scholar, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India.   
    2Associate Professor, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India.                                      
    3Assistant Professor, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India.
    4Professor, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India.
     

Abstract

In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Commiphora opobalsamum (L.) Engl. belongs to the Burseraceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as quercetin, syringic acid, canophyllal, friedelin, and oleanonic acid that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antiulcer, hepatoprotective, antihypertensive, antidiabetic, analgesic & anti?inflammatory, vasodilator, anticancer, antiseptic, anticoagulatant, antibacterial, antiviral, antioxidant, etc. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for Commiphora opobalsamum. Therefore, an updated, critical, and extensive overview on the current knowledge of Commiphora opobalsamum botanical description, phytochemical composition, pharmacological activities & toxicity profile is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well?being.

Keywords

Commiphora opobalsamum, Burseraceae, Phytochemistry, Ameliorative effect, Hepatoprotective, Toxicity profile

Reference

  1. Gohil KJ, Patel JA, Gajjar AK. Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian journal of pharmaceutical sciences. 2010 Sep;72(5):546.
  2. Khan LM, Kamel FO, Al-Salmi AA, Ahmad MA. Evaluation of the toxicological profile of commiphora opobalsamum in wister rats for its safety and rational use. Journal of Pharmaceutical Research International. 2021 Mar 30;33(19A):31-42.
  3. Khare C.P, Indian medicinal plant an illustrated dictionary, springer science illustrated dictionary, springer science and business media 2008,47-48.
  4. Suleiman MH. Prenylated flavonoids from the stem wood of Commiphora opobalsamum (L.) Engl. (Burseraceae). Journal of King Saud University-Science. 2015 Jan 1;27(1):71-5.
  5. Shen T, Li GH, Wang XN, Lou HX. The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology. 2012 Jul 13;142(2):319-30.
  6. Wineman E, Douglas I, Wineman V, Sharova K, Jaspars M, Meshner S, Bentwich Z, Cohen G, Shtevi A. Commiphora gileadensis sap extract induces cell cycle-dependent death in immortalized keratinocytes and human dermoid carcinoma cells. Journal of herbal medicine. 2015 Dec 1;5(4):199-206.
  7. Abbas FA, Al-Massarany SM, Khan S, Al-Howiriny TA, Mossa JS, Abourashed EA. Phytochemical and biological studies on Saudi Commiphora opobalsamum L. Natural product research. 2007 May 1;21(5):383-91.
  8. . Batiha GE, Wasef L, Teibo JO, Shaheen HM, Zakariya AM, Akinfe OA, Teibo TK, Al-Kuraishy HM, Al-Garbee AI, Alexiou A, Papadakis M. Commiphora myrrh: A phytochemical and pharmacological update. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Mar;396(3):405-20.
  9. Akbar S, Akbar S. Commiphora gileadensis (L.) C. Chr (Burseraceae) (Syn.: C. opobalsamum (L.) Engl.). Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications. 2020:695-9.
  10. Shen T, Wan W, Yuan H, Kong F, Guo H, Fan P, Lou H. Secondary metabolites from Commiphora opobalsamum and their antiproliferative effect on human prostate cancer cells. Phytochemistry. 2007 May 1;68(9):1331-7.
  11. Suleiman MH. Prenylated flavonoids from the stem wood of Commiphora opobalsamum (L.) Engl. (Burseraceae). Journal of King Saud University-Science. 2015 Jan 1;27(1):71-5.
  12. Yang JL, Shi YP. Cycloartane-type triterpenoids and sesquiterpenoids from the resinous exudates of Commiphora opobalsamum. Phytochemistry. 2012 Apr 1;76:124-32.
  13. Al-Howiriny TA, Al-Yahya MA, Al-Said MS, El-Tahir KE, Rafatullah S. Studies on the pharmacological activities of an ethanol extract of balessan (Commiphora opobalsamum). Pakistan Journal of Biological Sciences. 2004;7(11):1933-6.
  14. Al-Howiriny T, Al-Sohaibani M, Al-Said M, Al-Yahya M, El-Tahir K, Rafatullah S. Effect of Commiphora opobalsamum (L.) Engl.(Balessan) on experimental gastric ulcers and secretion in rats. Journal of ethnopharmacology. 2005 Apr 26;98(3):287-94.
  15. Al-Howiriny TA, Al-Sohaibani MO, Al-Said MS, Al-Yahya MA, El-Tahir KH, Rafatullah S. Hepatoprotective properties of Commiphora opobalsamum (" Balessan"), a traditional medicinal plant of Saudi Arabia. Drugs Exp Clin Res. 2004 Jan 1;30(5-6):213-0.
  16. . Amani S, Alzoreqy A, Al-Dbhani A, Al-Fteih L, Abu-Al-fatah T, QojaNazer H, Alnoor E. Therapeutic and preventive effects of Commiphora gileadensis against diethylnitrosamine-induced hepatic injury in albino rats. African Journal of Pharmacy and Pharmacology. 2016 Apr 29;10(16):356-63.
  17. Abdul-Ghani AS, Amin R. Effect of aqueous extract of Commiphora opobalsamum on blood pressure and heart rate in rats. Journal of ethnopharmacology. 1997 Aug 1;57(3):219-22.
  18. Farid MM, Aboul Naser AF, Salem MM, Ahmed YR, Emam M, Hamed MA. Chemical compositions of Commiphora opobalsamum stem bark to alleviate liver complications in streptozotocin-induced diabetes in rats: Role of oxidative stress and DNA damage. Biomarkers. 2022 Oct 14;27(7):671-83.
  19. Al-Salmi AA, Sattar MA, Khan LM, Al-Harthi SE. Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents. African Journal of Pharmacy and Pharmacology. 2015 Aug 29;9(32):806-17.
  20. Aljadaani BS, Bakr AA, Hamza AH. Effect of Ginkgo biloba and Commiphora opobalsamum extracts on liver fibrosis and kidney injury induced by carbon tetra chloride in experimental models. World Journal of Pharmaceutical Sciences. 2016 Jan 30:148-52.
  21. Gao W, Dong X, Xie N, Zhou C, Fan Y, Chen G, Wang Y, Wei T, Zhu D. Dehydroabietic acid isolated from Commiphora opobalsamum causes endothelium-dependent relaxation of pulmonary artery via PI3K/Akt-eNOS signaling pathway. Molecules. 2014 Jun 23;19(6):8503-17.
  22. Amiel E, Ofir R, Dudai N, Soloway E, Rabinsky T, Rachmilevitch S. ?-Caryophyllene, a compound isolated from the biblical balm of gilead (Commiphora gileadensis), is a selective apoptosis inducer for tumor cell lines. Evidence-based complementary and alternative medicine. 2012 Oct;2012.
  23. Salman A, Althobiti S. Evaluation of the potential protective effect of Commiphora gileadensis on CCL4-induced genotoxicity in mice. Egyptian Journal of Chemistry. 2023 Dec 1;66(13):1935-44.
  24. Althurwi HN, Salkini MA, Soliman GA, Ansari MN, Ibnouf EO, Abdel-Kader MS. Wound Healing Potential of Commiphora gileadensis Stems Essential Oil and Chloroform Extract. Separations. 2022 Sep 8;9(9):254.
  25. Alhazmi AS. Anticoagulative activity of Commiphora gileadensis, aspirin, and heparin on blood coagulation profiles in naïve mice. International Journal of Health Sciences. 2024 Jan;18(1):10.
  26. Alhazmi A, Aldairi AF, Alghamdi A, Alomery A, Mujalli A, Obaid AA, Farrash WF, Allahyani M, Halawani I, Aljuaid A, Alharbi SA. Antibacterial Effects of Commiphora gileadensis Methanolic Extract on Wound Healing. Molecules. 2022 May 21;27(10):3320.
  27. Ali SS, Al–Salmi AA, Ahmad MA, Khan LM. Sub-acute Toxicity and Safety Study of Mecca Myrrh (Commiphora opobalsamum) by Experimental Histological Analysis. Journal of Pharmaceutical Research International. 2022 Mar 21:13-23.
  28. Khan LM, Kamel FO, Al-Salmi AA, Ahmad MA. Evaluation of the toxicological profile of commiphora opobalsamum in wister rats for its safety and rational use. Journal of Pharmaceutical Research International. 2021 Mar 30;33(19A):31-42.

Photo
Manish G. Wanjari
Corresponding author

Research Scholar, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India

Photo
Deorao M. Awari
Co-author

Assistant Professor, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India

Photo
Sadhana P. Gautam
Co-author

Assistant Professor, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India

Photo
Bhushan R. Gandhare
Co-author

Professor, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India.

Photo
Ankit S. Kediya
Co-author

Associate professor, Department of Pharmacology, VYWS, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, Maharashtra, India.

Manish G. Wanjari, Deorao M. Awari, Sadhana P. Gautam, Bhushan R. Gandhare, Ankit S. Kediya, From Roots To Remedies: A Review Of Commiphora Opobalsamum- Plant Features, Phytochemistry, Pharmacological Insights And Safety, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 545-557. https://doi.org/Manish G. Wanjari, Deorao M. Awari, Sadhana P. Gautam, Bhushan R. Gandhare, Ankit S. Kediya, From Roots To Remedies: A Review Of Commiphora Opobalsamum- Plant Features, Phytochemistry, Pharmacological Insights And Safety, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 545-557. https://doi.org/10.5281/zenodo.10686392

More related articles
Demographic Factors Based On Predicting Mental Hea...
Dr. Vijayalakshmi Kakulapati, Shaik Subhani, Gowripriya Kukunuri,...
A study of challenges and quality of life QoL issu...
Yash Srivastav, Akhandnath Prajapati, Adityanath Prajapati, Madha...
Management Of Psoriasis: A Global Clinical Challen...
Nusrat Nabi, Mohd Rafi Reshi, Mariya Muzaffar, Muzamil Muzaffar, ...
A Review On Application And Scopes For Dosage Forms Of Cissus Quadrangularis Ext...
Rohit R. Eklare, Mahesh M. Biradar, Anita S. Chavan, Vaishnavi K. Chavhan, Anjali G. Chopade, ...
Review on 'Polycystic kidney disease pathophysiology and prognosis'...
Seema Kashyap, Eshu Sahu, Bignesh Pradhan, Dali Kanwar, Chhabi Lal, ...
Formulation And Evaluation of Red Lentils Herbal Face Scrub...
Kiran Kekane, Akanksha Rayate, Prapti Vikhe, Tejashri Mulay, ...
Related Articles
A Review On Phytochemical And Pharmacological Significance Of Moringa Oleifera...
Arpitha G, Tejas P, Poojitha Wodeyar, Kalyani B. S. , Preethi S. M., Harish K. M., ...
A Review On The Analytical Method Development And Validation Of Sertralinetablet...
Ashishkumar Panpatil, Vedant Salunke , Snehal Jadhav, Faisal Shaikh, Pravin Jadhav, Vinod Bairagi, K...
Advances In Skin Lightening Agents: Mechanisms, Efficacy, And Safety Considerati...
Anushree P Munchinamane, Sirisha N. V. L. Mulukuri, Pankaj Kumar, Satheesh Madhav N. V, ...
A comprehensive review on Pharmacovigilance Enhancing Drug Safety and Surveillan...
Arkaydius Jyndiang, A. R. Shabaraya, Viresh K. Chandur, ...
Demographic Factors Based On Predicting Mental Health Of Caronavirus Victims...
Dr. Vijayalakshmi Kakulapati, Shaik Subhani, Gowripriya Kukunuri, Pallavi KSL Lakkoju, ...
More related articles
Demographic Factors Based On Predicting Mental Health Of Caronavirus Victims...
Dr. Vijayalakshmi Kakulapati, Shaik Subhani, Gowripriya Kukunuri, Pallavi KSL Lakkoju, ...
A study of challenges and quality of life QoL issues related to Vitiligo disease...
Yash Srivastav, Akhandnath Prajapati, Adityanath Prajapati, Madhaw Kumar, Mohammad Aqil Siddiqui, ...
Management Of Psoriasis: A Global Clinical Challenge And Future Treatment ...
Nusrat Nabi, Mohd Rafi Reshi, Mariya Muzaffar, Muzamil Muzaffar, Nausheen Yusuf, ...
Demographic Factors Based On Predicting Mental Health Of Caronavirus Victims...
Dr. Vijayalakshmi Kakulapati, Shaik Subhani, Gowripriya Kukunuri, Pallavi KSL Lakkoju, ...
A study of challenges and quality of life QoL issues related to Vitiligo disease...
Yash Srivastav, Akhandnath Prajapati, Adityanath Prajapati, Madhaw Kumar, Mohammad Aqil Siddiqui, ...
Management Of Psoriasis: A Global Clinical Challenge And Future Treatment ...
Nusrat Nabi, Mohd Rafi Reshi, Mariya Muzaffar, Muzamil Muzaffar, Nausheen Yusuf, ...