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Abstract

Toothpaste is a gel or paste formulation product and is used to clean and maintain oral hygiene with the aid of toothbrush. The majority of the cleaning is performed by the mechanical utilisation of the toothbrush with the help of excipients used in toothpaste. The aim of this investigation is to evaluate herbal toothpaste formulation. Herbal toothpaste with natural ingredients is more acceptable in public opinion than chemical-based formulation due to their safety and efficacy in reducing dental caries and preventing other dental disorders. The objective of the present research work is to formulate herbal toothpaste containing natural ingredients like Neem, Clove, Black-seed oil and walnut. These extracts have anti-bacterial, anti-caries, anti-ulcer, anti-oxidant and anti-fungal activities.The physicochemical evaluation of selected plants were within the pharmacopoeial limit and phytochemical screening in ethanol and water extracts showed the intensive presence of constituents like Alkaloid, Flavonoids, Glycosides, Phenols and tannins. The formulated herbal toothpaste were evaluated to determine important physical characteristics such as pH, Foamability, Spreadability, Abrasiveness, Extrudability and Shape retention in order to develop a more effective and stable product. All in-vitro evaluations of prepared herbal toothpaste showed better result. The developed formulation showed anti-bacterial activity against bacterial culture and produced a better zone of inhibition.The purpose of this project is to make and test the prepared herbal toothpaste. This research proves that our herbal based toothpaste formulation with natural ingredients is excellent as it gets in terms of performance.

Keywords

Herbal toothpaste,Oral hygiene,Anti-bacterial,Dental care.

Reference

  1. M Surya, S Gunasekaran. A Review on Recent Scenario of Cosmetics. International Journal of Pharmaceutical Science and Research, 2021;68(1):190-197
  2. Khushbu Yadav, Satyam Prakash. Dental carries: A Review. Asian Journal of Biomedical and Pharmaceutical Science, 2016;6(53):01-07
  3. Chenj Jacox LA, Saldanha F, Sive HMouth development. Willey Interdiscip Rev Dev Biol,2017:6(5),103-112
  4. Gupta PC. Gutka: A major new tobacco hazard in. India, Tobacco Control, 1999, 8: 134
  5. Prashant Yadav, Kanhiya Mahour and Ashok kumar. Standardization And Evaluation Of Herbal Drug Formulation. Journal Of Advanced Laboratory Research, 2011;4(2):0976-7614
  6. Sumith Kumar M, Vandhana Swarnkar, Sohani Sharma. Herbal Cosmetics Used For The Skin And Hair. Inventi Journals (p) Ltd.2012;4:0976-3864
  7. Durgesh Gautam, Preetam Palkar, Kiran Maule, Shilpa Singh. Preparation, Evaluation And Comparison Of Herbal Toothpaste With Marketed Herbal Toothpaste Asian Journal Of Pharmacy And Technology, 2020; 10(3): 2231-5713.
  8. Abdelhady MIS, Bader A, Shaheen U, El-Malah Y, Abourehab MAS, Barghash MF. Azadirachta indica as a source for antioxidant and cytotoxic polyphenolic compounds. Niosci Biotech Res Asia. 2015;12:1209–1222.
  9. Atawodi SE, Atawodi JC. Azadirachta indica (neem): a plant of multiple biological and pharmacological activities. Phytochem Rev. 2009;8:601–620.
  10. Nassar, Ahmed. H. Chemical constituents of clove (Syzygium aromaticum fam Myrtaceae) and their antioxidant activity. Rev. Latinoamer quim, 2007;35(3):25-43
  11. Gaber E I-Saber Batiha, Luaym MA Alkazmi. Syzygium aromaticum L. (Myrtacea) Traditional uses, Bioactive chemical constituents, Pharmacological and Toxicological activities. Biomolecule, 2020;10(2):202
  12. Shah TI, Akthar S, Ganesh N. Prelimnary phytochemical evaluation and anti- bacterial potential of different leaf extracts of J. regia: A ubiquitous dry fruit from Kashmir-India. Pharm Sci Rev Res. 2013;19:93–6
  13. Somesh Anand Mali, Sameer Mafijioor Malik, Aakansha Anil Mane. Formulation And Evaluation Of Herbal Toothpaste. International Journal Of Pharmaceutical Research And Application, 2022; 7(5): 1380-1386
  14. Pavan Deshmukh,Roshan, Telrandhe.Formulation and evaluation of herbal tooth paste compared with marketed preparation.International Journal of Pharmaceutics and DrugAnalysis,2017;10:406-410
  15. Geroge J,HegdeS,KSR,KumarA.The efficacy of herbal based toothpaste in the control of Plaque and gingivitis.A Clinical Biochemical Study.Indian J Res,2009;20(4):408-482
  16. R P Buck,SRodinini,ArthurkCovington.Measurement Of pH Definition, Standards, and Procedure. International Union of Pure and Applied Chemistry,2002;74(11)2169- 2200
  17. Vasantrio Bhagwan Kadam. Determination of Ash value of Some medicinal plants of Marathwada Region in Maharashtra. International Journal of Pharmaceutical Research andBio-Science, 2012:1(3):337-346
  18. Vijay Kothari, Ankit Gupta, Madhu Naraniwal. Extraction Method of Preperation of Bio active Plant extract. Journal of Applied Science, 2010;10(21):2713-2716
  19. Sullivan, M F Kalkwarf. Sustained release of naltrexone from glyceride implants. National Institute Drug Abuse Res Monogrser,1976;1:27-32
  20. A K Azad, M Awang, MM Rahman. Determination of Extractive valve and Phytochemical analysis of Bacopa-monnieri (1) Penn. International Journal of Current Pharmaceutical Review and Research, 2008;3(3):66-78
  21. Edina Vranic, Amela Lacevic, Aida Mehmedagic. Formulation Ingredients For Toothpaste And Mouthwash. Bosan J Basic Med Science, 2004 ; 4(4) : 51-58
  22. Vijay Kothari, Ankit Gupta, Madhu Naraniwal. Extraction Method of Preperation of Bio active Plant extract. Journal of Applied Science, 2010;10(21):2713-2716
  23. Abeer M.Ismail, Eman A Mohamed, Marwa R. Marghany. Preliminary Phyto Chemical Screening. Plant Growth Inhibition And Antimicrobial Activity. Journal Of The Saudi Society Of Agricultural Sciences, 2016;15(2):112-117
  24. Sanjay K.Bais, Kajal S., “Mechanisms of bacterial pathogenicity,” Postgraduate Medical Journal, vol. 78,no. 918, pp. 216–224, 2002.
  25. S.M. Sahidullah, SumayehBeegum. et al., “Rethinking the history of common walnut (Juglans regia L.) in Europe: its origins and human interactions,” vol. 12, no. 3, Article ID e0172541, 2017.
  26. M. Yelne, P. Sharma, and T. Dennis, Database on Medicinal Plants Used in Ayurveda, Vol. 4, Central Council for Research in Ayurveda & Siddha, Chennai, India, 2002.
  27. F. Zakavi, L. Golpasand Hagh, A. Daraeighadikolaei, Shooshtari, “Antibacterial effect of Juglans regia bark against oral pathologic bacteria,” International Journal of Dentistry, vol. 2013, Article ID 854765, 5 pages, 2013.
  28. Riham AI-Ravi, Yusra Bashir et aletal.,“Antimicrobial activity of different extracts of Juglans regia L. against oral microflora,” International Journal of Pharmacy and Pharmaceutical Sci- ences, vol. 3, no. 2, pp. 200-201, 2011.
  29. M. Alkhawajah, “Studies on the antimicrobial activity of Juglans regia,” The American Journal of Chinese Medicine, vol. 25, no. 2, pp. 175–180, 1997.
  30. Anna T, Collins L. Remineralization Of Potential Of Evaluation Of Toothpaste: An Ire Vitro Study. The J.Of Cont. Dent. Practice, 2004; 5(1): 1-2

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Sharanya R.K
Corresponding author

Department of pharmaceutics,Rajiv Gandhi institute of pharmaceutical science and research

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Fathimath Fitha M.A
Co-author

Rajiv Gandhi institute of pharmceutical science and research

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Anisa A
Co-author

Rajiv Gandhi institute of pharmaceutical science and research

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Muhammed sahadath K
Co-author

Rajiv Gandhi institute of pharmaceutical science and research

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Thanveera kunheeritheeri
Co-author

Rajiv Gandhi institute of pharmaceutical science and research

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Sameena P.L
Co-author

Rajiv Gandhi institute of pharmaceutical science and research

Sharanya R. K. , Fathimath Fitha M. A. , Anisa A. , Muhammed Sahadath K. , Sameena P. L. , Thanveera Kunheeritheeri , Formulation And Evaluation Of Polyherbal Toothpaste, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 9, 1333-1340. https://doi.org/Sharanya R. K. , Fathimath Fitha M. A. , Anisa A. , Muhammed Sahadath K. , Sameena P. L. , Thanveera Kunheeritheeri , Formulation And Evaluation Of Polyherbal Toothpaste, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 9, 1333-1340. https://doi.org/10.5281/zenodo.13850938

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