View Article

Abstract

Solubility is the process of dissolution of a solute in solvent, which is essential to formulate number of dosage forms. Bioavailability of drugs can be improved by increasing the solubility of drugs. To design oral formulations using drug candidates with poor solubility is a big challenge in pharmaceuticals. Solubility of drugs can be enhanced by different techniques by modifying their chemical properties, physical characteristics and by converting the drugs into their salt forms. Few methods to increase solubility of poorly soluble drugs is reviewed in this study.

Keywords

Solubility, enhancement, co-solvency, solid dispersion

Reference

  1. Youn YS, Jung JY, Oh SH, Yoo SD, Lee KC. Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy. Journal of controlled release. 2006 Sep 12;114(3):334-42.Universal Journal of Pharmaceutical Research. 2017;2(5):50-5.
  2. Ohara T, Kitamura S, Kitagawa T, Terada K. Dissolution mechanism of poorly water-soluble drug from extended release solid dispersion system with ethylcellulose and hydroxypropylmethylcellulose. International journal of pharmaceutics. 2005 Sep 30;302(1-2):95-102.
  3. Saindane DS, Kulkarni AS, Khade TS, Patil MD. Enhancing drug solubility and oral bioavailability using solid dispersions: A review. Int J Biopharm. 2011;2(1):22-30.
  4. Dixit AK, Singh RP, Singh S. Solid dispersion-a strategy for improving the solubility of poorly soluble drugs. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012;3(2):960-6.
  5. Singh S, Baghel RS, Yadav L. A review on solid dispersion. International journal of pharmacy & life sciences. 2011 Sep 1;2(9)
  6. Hasegawa S, Hamaura T, Furuyama N, Kusai A, Yonemochi E, Terada K. Effects of water content in physical mixture and heating temperature on crystallinity of troglitazone-PVP K30 solid dispersions prepared by closed melting method. International journal of pharmaceutics. 2005 Sep 30;302(1-2):103-12.
  7. Lloyd GR, Craig DQ, Smith A. A calorimetric investigation into the interaction between paracetamol and polyethlene glycol 4000 in physical mixes and solid dispersions. European journal of pharmaceutics and biopharmaceutics. 1999 Jul 1;48(1):59-65
  8. Jain P, Goel A, Sharma S, Parmar M. Solubility enhancement techniques with special emphasis on hydrotrophy. International Journal of Pharma Professional’s Research (IJPPR). 2010;1(1):34-45.
  9. Löbenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. European journal of pharmaceutics and biopharmaceutics. 2000 Jul 3;50(1):3-12.
  10. Bergström CA, Strafford M, Lazorova L, Avdeef A, Luthman K, Artursson P. Absorption classification of oral drugs based on molecular surface properties. Journal of medicinal chemistry. 2003 Feb 13;46(4):558-70.
  11. Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. Journal of pharmaceutical sciences. 1971 Sep 1;60(9):1281-302.
  12. Bajait MG, Ghatmale R, Mundhe B. Importance of solubility and solubility enhancement techniques. J. Medi. Pharm. Allied. Sci.. 2019;878:2403-16
  13. Beig A, Miller JM, Lindley D, Carr RA, Zocharski P, Agbaria R, Dahan A. Head-to-head comparison of different solubility-enabling formulations of etoposide and their consequent solubility–permeability interplay. Journal of pharmaceutical sciences. 2015 Sep 1;104(9):2941-7.
  14. Loh ZH, Samanta AK, Heng PW. Overview of milling techniques for improving the solubility of poorly water-soluble drugs. Asian journal of pharmaceutical sciences. 2015 Jul 1;10(4):255-74
  15. kadam SV, Shinkar DM, Saudagar RB. Review on solubility enhancement techniques. IJPBS. 2013;3(3):462-75.
  16. Jatwani S, Rana AC, Singh G, Aggarwal G. An overview on solubility enhancement techniques for poorly soluble drugs and solid dispersion as an eminent strategic approach. International journal of pharmaceutical Sciences and Research. 2012 Apr 1;3(4):942
  17. Kadam SV, Shinkar DM, Saudagar RB. Review on solubility enhancement techniques. IJPBS. 2013;3(3):462-75.
  18. Gowardhane AP, Kadam NV, Dutta S. Review on enhancement of solubilization process. Am. J. Drug Discov. Dev. 2014;4(2):134-52.
  19. Kotak U, Prajapati V, Solanki H, Jani G, Jha P. Co-crystallization technique its rationale and recent progress. World J Pharm Pharm Sci. 2015;4(4):1484-508.
  20. Miroshnyk I, Mirza S, Sandler N. Pharmaceutical co-crystals–an opportunity for drug product enhancement. Expert opinion on drug delivery. 2009 Apr 1;6(4):333-41.
  21. Patole T, Deshpande A. Co-crystallization-a technique for solubility enhancement. International journal of pharmaceutical sciences and research. 2014 Sep 1;5(9):3566.
  22. Vemula VR, Lagishetty V, Lingala S. Solubility enhancement techniques. International journal of pharmaceutical sciences review and research. 2010 Nov;5(1):41-51.
  23. Chaudhari PD, Uttekar PS. Melt-sonocrystallization: a novel particle engineering technique for solubility enhancement. Int J Pharm Tech Res. 2009 Jan;1(1):111-20.
  24. Vemula VR, Lagishetty V, Lingala S. Solubility enhancement techniques. International journal of pharmaceutical sciences review and research. 2010 Nov;5(1):41-51.
  25. Kamalakkannan V, Puratchikody A, Masilamani K, Senthilnathan B. Solubility enhancement of poorly soluble drugs by solid dispersion technique–A review. J. Pharm. Res. 2010 Sep;3(9):2314-21.
  26. Singh MC, Sayyad AB, Sawant SD. Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion. J Pharm Res. 2010 Oct;3(10):249-50.
  27. Jain S, Patel N, Lin S. Solubility and dissolution enhancement strategies: current understanding and recent trends. Drug development and industrial pharmacy. 2015 Jun 3;41(6):875-87.
  28. Gowardhane AP, Kadam NV, Dutta S. Review on enhancement of solubilization process. Am. J. Drug Discov. Dev. 2014;4(2):134-52.
  29. Kumar A, Kumar K. Solid dispersion-strategy to enhance solubility and dissolution of poorly water soluble drugs. Universal Journal of Pharmaceutical Research. 2017;2(5):50-5.
  30. Bhaskar R, Monika OL, Ghongade RM. Solid Dispersion Technique for Enhancement of Solubility of Poorly Soluble Drug. Indian journal of pharmaceutical and biological research. 2018 Jun 30;6(02):43-52.
  31. Kakumanu VK, Bansal AK. Supercritical fluid technology in pharmaceutical research. Crips. 2003;4(83):8-12.
  32. Won DH, Kim MS, Lee S, Park JS, Hwang SJ. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. International journal of pharmaceutics. 2005 Sep 14;301(1-2):199-208.
  33. Sawicki E, Schellens JH, Beijnen JH, Nuijen B. Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies. Drug Development and Industrial Pharmacy. 2017 Apr 3;43(4):584-94.
  34. Robert CJ, Armas HN, Janssen S: Characterization of ternary solid dispersion of intraconazole PEG 6000. J Pharm Sci. 2008; 97: 2110-2120
  35. Jatwani S, Rana AC, Singh G, Aggarwal G. An overview on solubility enhancement techniques for poorly soluble drugs and solid dispersion as an eminent strategic approach. International journal of pharmaceutical Sciences and Research. 2012 Apr 1;3(4):942

Photo
Arpitha G.
Corresponding author

Shridevi Institute of Pharmaceutical Sciences, Tumkur

Photo
Harshitha T. P.
Co-author

Shridevi Institute of Pharmaceutical Sciences, Tumkur

Photo
Madhu G. R.
Co-author

Shridevi Institute of Pharmaceutical Sciences, Tumkur

Photo
Jamuna K. R.
Co-author

Shridevi Institute of Pharmaceutical Sciences, Tumkur

Photo
Maruthi T. Kovi
Co-author

Shridevi Institute of Pharmaceutical Sciences, Tumkur

Photo
Jeevan S.
Co-author

Shridevi Institute of Pharmaceutical Sciences, Tumkur

Arpitha G. , Harshitha T. P. , Madhu G. R. , Jamuna K. R. ,Maruthi Thippanna Kovi, Jeevan S. , An Overview On Various Techniques To Enhance Solubility Of Poorly Soluble Drugs, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 316-322. https://doi.org/10.5281/zenodo.10653108

More related articles
A Review: Introduction To Vitamin B12 & Its Associ...
Drashti N Bhalodia, Dharmendrasinh A Baria, ...
Nanoemulgel As A Novel Carrier for Topical Drug De...
Manjunath T., Ganesh N. S., Adlin Jino Nesalin, Vineeth Chandy, ...
Atovaquone: A Comprehensive Review of Its Antimicr...
Tejaswini Gedam, Dr. Nilesh Chachda , Gaurav Meshram , ...
Determination Of Saturated Solubility Of Cyclobenzaprine HCL Using UV Visible Sp...
Indrani Madala , J Adlin, Jino Nesalin, E Gopinath, , N S Ganesh , Vineeth Chandy, ...
Formulation And Evaluation of Ibuprofen Tablets Using Hydrotropic Solid Dispersi...
Neha Shivathaya, Aliza Bagaban, Suhel Mulla, Nivedita Kappattanavar, Sahana Khavatakoppa, Swaroop Ka...
Emerging Therapeutic Approaches in Women's Reproductive Health: Current Advances...
Manjari, Pooja Khanpara, Anil Kumar, E. Latha, Eldhose M. J., Selvakumar Sambandan, Manorama, Yash S...
Related Articles
Moringa Oleifera Tablets: A Comprehensive Review of Novel Formulation Techniques...
Shilpa Jaiswal, Kaushal Borkar , Gayatri Argulwar , Sanket Deshmukh, Dr. M. D. Kitukale, ...
Supersaturated Drug Delivery System: An Approach To Enhance The Bioavailability...
MANOJ R. V., Parthasarathi K. Kulkarni, Nagendra R., Venkatesh K., Hanumanthachar Joshi, ...
Topical Drug Innovation: Past, Present And Future Prospects ...
Ankita Damahe, Aditi Sharma, Shakuntala Pal, Anusha Sinha , Himanshu Bhuarya, ...
More related articles
Nanoemulgel As A Novel Carrier for Topical Drug Delivery System: A Brief Review...
Manjunath T., Ganesh N. S., Adlin Jino Nesalin, Vineeth Chandy, ...
Atovaquone: A Comprehensive Review of Its Antimicrobial Efficacy and Mechanism o...
Tejaswini Gedam, Dr. Nilesh Chachda , Gaurav Meshram , ...
Nanoemulgel As A Novel Carrier for Topical Drug Delivery System: A Brief Review...
Manjunath T., Ganesh N. S., Adlin Jino Nesalin, Vineeth Chandy, ...
Atovaquone: A Comprehensive Review of Its Antimicrobial Efficacy and Mechanism o...
Tejaswini Gedam, Dr. Nilesh Chachda , Gaurav Meshram , ...