View Article

Abstract

Neurons are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from external world. Neurological disabilities include a wide range of disorder, such as epilepsy learning disabilities, neuromuscular disorders, autism, attention deficit disorder, brain tumours and cerebral palsy. Neuroprotection is the ability for a therapy to prevent neuronal cell death by intervening in and inhibiting the pathogenetic cascade that results in cell dysfunction and eventual death. Numerous natural products, but primarily plant extracts, have been reported to be used in traditional medicine for neuroprotective, memory enhancing, and antiaging purposes. Calotropis Procrera known as “milkweeds “which comes under the family of Apocyanacece. Ethanolic extract of Calotrpis procera that contains active chemical constituents such as flavonoids, tannins, phenols show neuroprotective activity. In view of this, the present study was aimed to evaluate neuroprotective activity of ethanolic extract of leaves of Calotropis Procrea in neuropathy induced rat model.

Keywords

Neurological disorder, Neuroprotective activity, Calotropis procera

Reference

  1. Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the UK. Diabetes care. 2011 Oct 1;34(10):2220-4. 
  2. Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annual review of neuroscience. 2009 Jul 21;32:1-32.
  3. Potashkin J, Seidl SE. The promise of neuroprotective agents in Parkinson’s disease. Frontiers in neurology. 2011 Nov 21;2:68. 
  4. Dunnet SB, Borklund A. Prospects for new retrospective and neuroprotective treatment in Parkinson’s disease. Nature. 1999;399. 
  5. Zhang WE, Wang T, Qin L, Gao HM, Wilson B, Ali SF, Zhang W, Hong JS, Liu B. Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase. The FASEB journal. 2004 Mar;18(3):589-91.
  6. Zádori D, Klivényi P, Szalárdy L, Fülöp F, Toldi J, Vécsei L. Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: novel therapeutic strategies for neurodegenerative disorders. Journal of the neurological sciences. 2012 Nov 15;322(1-2):187-91. (25)
  7. Lorke D. A new approach to practical acute toxicity testing. Archives of toxicology. 1983 Dec;54(4):275-87. 
  8. Austin PJ, Wu A, Moalem-Taylor G. Chronic constriction of the sciatic nerve and pain hypersensitivity testing in rats. JoVE (Journal of Visualized Experiments). 2012 Mar 13(61):e3393. 
  9. Bertelli JA, Mira JC. The grasping test: a simple behavioral method for objective quantitative assessment of peripheral nerve regeneration in the rat. Journal of neuroscience methods. 1995 May 1;58(1-2):151-5.

Photo
Priya Patil
Corresponding author

MTRIPS, HKE’s College of Pharmacy, Kalaburagi-585105

Photo
Dr. Nitin mahurkar
Co-author

MTRIPS, HKE’s College of Pharmacy, Kalaburagi-585105

Photo
Aatefa harmyn
Co-author

MTRIPS, HKE’s College of Pharmacy, Kalaburagi-585105

Priya Patil*, Dr. Nitin mahurkar, Aatefa harmyn, Neuroprotection Of Calotropis Procera Leaf Extract In Neuropathy Induced Rat Model, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 236-243. https://doi.org/10.5281/zenodo.10046002

More related articles
To Ensure Patient Safety In Bhaktivedanta Hospital...
Deepak Mali, Narendra Pande, Haripriya Tinani , Gajanan Ramtake, ...
Anti Ulcer Activity Of Medicinal Plants ...
Gauri S Salunke , Gayatri B Gaware , Rupali N Tarde , Payal A Pan...
Tolvaptan : Vasopressin Antagonist for Hyponatremi...
Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree, Saripella...
Effective Communication In Pharmacovigilance...
Prajakta Pujari , Sonali Magdum, Kajal Shinde, Darshani Taral, Prajakta Chaugule, Sadhana Pujari, Ra...
Harnessing the Plant Kingdom: A Review of Herbal Immunostimulants...
prathisha v, shridevi s, keshava murthy S G , ...
Recent advances in clinical evaluation of antiulcer drug...
Tejaswini S. Kamble, Vishavjeet S. Pisal, Pritam Salokhe, sachin Navale, Nilesh Chougule, ...
Related Articles
A Comparative Analysis Of In-Process Quality Control Parameters Of Montelukast S...
Trupti Yogesh Pawar, Tanishka Anil Pawar, Rahul Keshav Godge, ...
Method Development And Validation Of Asciminib By RP-HPLC ...
Ogale Shital Ashokrao, Madhav A Shetkar, S S Patil, ...
A Review On Biomedical Applications Of Antifungal Microemulsions...
Soham bagul, Dhiraj Hiray, Vedant dusane, Shruti ghatmale, ...
Formulation And Evaluation Of Mucoadhesive Film For The Treatment Of Migraine ...
Muthamil C , Sreedharan.N.K.K, Dr. Senthilkumar.K.L, ...
To Ensure Patient Safety In Bhaktivedanta Hospital & Research Institute By Conti...
Deepak Mali, Narendra Pande, Haripriya Tinani , Gajanan Ramtake, Ila Gosh , Kailas M., Sivaprasad G....
More related articles
To Ensure Patient Safety In Bhaktivedanta Hospital & Research Institute By Conti...
Deepak Mali, Narendra Pande, Haripriya Tinani , Gajanan Ramtake, Ila Gosh , Kailas M., Sivaprasad G....
Anti Ulcer Activity Of Medicinal Plants ...
Gauri S Salunke , Gayatri B Gaware , Rupali N Tarde , Payal A Pangude , Sayyed Afnan kirmani, ...
Tolvaptan : Vasopressin Antagonist for Hyponatremia...
Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree, Saripella Jaya Sree, ...
To Ensure Patient Safety In Bhaktivedanta Hospital & Research Institute By Conti...
Deepak Mali, Narendra Pande, Haripriya Tinani , Gajanan Ramtake, Ila Gosh , Kailas M., Sivaprasad G....
Anti Ulcer Activity Of Medicinal Plants ...
Gauri S Salunke , Gayatri B Gaware , Rupali N Tarde , Payal A Pangude , Sayyed Afnan kirmani, ...
Tolvaptan : Vasopressin Antagonist for Hyponatremia...
Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree, Saripella Jaya Sree, ...