NRI College of Pharmacy, Pothavarappadu, Vijayawada 521212
Vertigo is uncomfortable symptom of either vestibular or neurological pathology; it is a condition that is marked by a spinning feeling, lack of balance, nausea, and tinnitus. It is multifactorial in nature and some causes are peripheral ear disorders, lesions at the central nervous system, vascular insufficiency, metabolic diseases, infections and stress. The traditional management is using a vestibular suppressant, antiemetic, diuretics, corticosteroids and migraine prophylaxis. Such agents are acutely effective but have a limitation of sedation, dependence, or slow vestibular compensation, and hence safer, long-term approaches are warranted. Herbal medicines employed in traditional Ayurveda, Traditional Chinese Medicine (TCM) and folk medicine are finding their way as complements. Their clinical utility is based on the fact that they enhance microcirculation, lessen oxidative stress, alter neurotransmitters and have anti-inflammatory and antiemetic effects. Ginkgo biloba improves cerebral and inner ear blood circulation with evidence in Méniere disease and vascular vertigo. Ginger treats nausea and inflammation of the vestibular in connection with motion sickness. Neuroprotective adaptogenic herbs such as Ashwagandha, Brahmi and Gotu kola relieve stress, enhance cognitive and balance capabilities. Coriander, Tulsi, Chamomile, Lemon balm and Valerian are antioxidants, anxiolytic, and sedatives that can be used in psychogenic or stress-related vertigo. Plants like Garlic, Cinnamon, Clove, Licorice, Feverfew, and Skullcap are known to aid a circulatory or anti-inflammatory or neuroprotective activity. Although usually safe, herb-drug interactions (e.g. with anticoagulants, sedatives, and antihypertensives) and changeability in phytochemical composition are of concern. More standardization and clinical trials should be conducted to prove efficacy. Overall, herbal interventions provide a multi-factorial, holistic management method of vertigo, and their combination with standard treatment could help better treat patients with minimal side effects.
Vertigo is a frequent complaint in primary care and emergency settings, characterized as a sensation of motion, generally rotational, due to vestibular dysfunction. Accurate isolation of vertigo from other forms of dizziness, such as presyncope, disequilibrium, or flightiness, is essential for effective opinion and operation. [1] This symptom affects individualities across all age groups. In adolescent cases, vertigo generally arises from inner ear pathology. In aged grown-ups, targeted assessment is critical, as central causes of vertigo, which are more current in this population, increase the threat of falls and related complications, challenging precise evaluation to ensure applicable treatment and enhanced patient outcomes. [2]
Traditionally, plants have been used as the main drug source by humankind since ancient times and are the base of traditional drug systems like Ayurveda, Traditional Chinese Medicine and Unani. To this day, herbal remedies still form an essential part of healthcare system because they're available, considered safe to use and applicable within societies. Herbal drugs have many bioactive compounds of which they belong to alkaloids, flavonoids, glycosides, tannin and essential oils which are came by using different parts of plants stems, leaves, flowers, fruits and seeds. These phytochemicals play functions in a wide variety of pharmacological actions to carry these out there areanti-inflammatory, antimicrobial, antioxidant, analgesic, and immune modulators.
Herbal remedies are also being researched in the current healthcare culture as an alternative or addition to treatment of many kinds of conditions in healthcare-chronic conditions, like diabetes, hypertension and arthritis to the common illnesses buried forehead, fever and skin infections. Herbal formulations could have a synergistic action on various pathways unlike synthetic medicines which tend to affect only one mechanism which results in action being holistic in nature therefore profitable in the operation of the disease. Also, the maturity of cases allow using herbal remedies because they've smaller side effects, reduced cost, and have long traditions in use. The significance of herbal drug has been conquered to increased interest around the world in the once decades, which can be explained by the increasing popularity and necessity of natural products, lifestyle related diseases and thefailings of conventional treatment. WHO also estimates that about 80 percent of the global community depends on herbs in terms of access to primary healthcare requirements. still, it must be scientifically validated to be safe, effective and to have a system of controlling quality. To incorporate herbal drugs into confirmation based on healthcare, standardization, pharmacological assessment and clinical trials are getting common.
EPIDEMIOLOGY:
Vertigo affects both men and women, but it's around 2 to 3 times more common in women than men( 1). This condition has been companied with various comorbid conditions, including depression and cardiovascular complaint. frequency increases with age and varies depending on the bolstering opinion; predicated on a general population check, the 1- time frequency of vertigo is about 5, and the periodic frequency is 1.4. Dizziness, including vertigo, affects about 15 to over 20 of grown- ups yearly. For benign ferocious positional vertigo, the 1- time frequency is about 1.6, and is lower than 1 for vestibular migraine.[3] The impact of vertigo should not be underrated, as nearly 80 of check attesters reported an interruption in exertion of quotidian living, including employment and the need for fresh medical attention. The frequency of Meniere complaint has been recently reported to be 0.51, which is important advanced than former reports. [3][4]
PATHOPHYSIOLOGY:
Abnormalities in the vestibular system account for the symptoms of vertigo and may affect from damage or dysfunction in the supplemental vestibular system, similar as the vestibular maze or vestibular whim-whams, or a disturbance in the central vestibular system set up in the brainstem and cerebellum.[1] Though there may be a endless vestibular disturbance, the symptom of vertigo is no wayendless as the central nervous system adapts over days to weeks.[5] Tumours can bring vertigo by contraction of the structures in the central vestibular system. Schwannoma is the most common lesion in the cerebellopontine angle. [6]Meningioma is the most common extra-axial tumour in grown-ups, and is the alternate most common lesion in the cerebellopontine angle. Glomus jugulare and glomus jugulotympanicum are the chemoreceptor system's main primary tumours of the jugular foramen. Metastases should be a consideration in cases with known primary tumors or multiple brain lesions. Infections can beget vertigo by involving the supplemental or central vestibular system, with viral labyrinthitis being the most common sample. Otomastoiditis is an infection of the tympanic and mastoid depressions commonly caused by bacterial agents, the most common being Streptococcus pneumoniae and Haemophilus influenza. Acute cerebellitis is an encephalitis that’s confined to the cerebellum. This condition is most common in children, and Varicella- zoster cancer is the leading cause. Cholesteatoma can be acquired or natural, being in the pars flaccida or pars tensa, caused by the abnormal proliferation of keratinized stratified squamous epithelium. [7]
Types of Vertigo
There are 2 types of vertigo -
1. Peripheral vertigo
Peripheral vertigo is the most common type of vertigo and is caused by problems in the inner ear, which controls our balance. It presents with symptoms such as spinning sensation, sweating, nausea, vomiting and ear problems. However, there can be pain or feeling of completeness in the ear, If supplemental vertigo is due to an infection in the inner ear.[8][9]
Causes of peripheral vertigo
Benign paroxysmal positional vertigo (BPPV) is the most common form of peripheral vertigo. This type of vertigo is easy to treat and hence correct diagnosis avoids inessential testing and costly treatment. BPPV is characterized by short-lived episodes of rotatory dizziness along with head movements. The usual time frame is nearly 45 seconds.
Trauma can also cause many types of vertigo including BPPV.
In treating BPPV, the Epley maneuver and Brandt-Daroff exercises that involve a series of guided head movements have been found to be helpful. Any hearing loss or ringing in the ears is treated with medication and hearing aids. A low salt diet, diuretic medications, and abstaining from alcohol can help with recovery.[8]
2. Central vertigo
Central vertigo mainly occurs due to brain injury or disease. It often appears suddenly and lasts longer than peripheral vertigo. The intensity is also greater. Patients may need assistance to walk or even stand.[10]
Causes of central vertigo
Vertigo associated with present day diseases
1. Neurological Disorders
2. Cardiovascular & Metabolic Diseases
3. Ear & Vestibular Disorders
4. Psychiatric & Stress-Related Disorders
5. Modern Lifestyle & Environmental Causes
Conventional Management of Vertigo
Vertigo is not a disease itself but a symptom of underlying vestibular or neurological disorders. Its management involves both pharmacological treatments to control acute symptoms and non-pharmacological interventions to address the root cause, promote central compensation, and improve quality of life. [21]
1. Pharmacological Management
a) Vestibular suppressants
Anticholinergics:
b) Antiemetics
c) Corticosteroids
d) Diuretics
e) Betahistine
f) Migraine Prophylaxis Drugs (in Vestibular Migraine)
2. Non-Pharmacological Interventions
a) Vestibular Rehabilitation Therapy (VRT)
b) Repositioning Maneuvers (for BPPV)
c) Lifestyle & Dietary Measures
d) Safety Measures
e) Psychological Support
f) Surgical / Interventional (for refractory cases)
ROLE OF HERBAL MEDICINE IN VERTIGO
For managing vertigo and associated symptoms like dizziness imbalance nausea and tinnitus, various systems of medicines are used traditionally such as ayurveda traditional Chinese medicine (TCM) and folk medicine.
Their benefits are stem from improving cerebral and vestibular circulation reducing oxidative stress regulating neuro transmitters and providing anti-inflammatory and antiemetic effects
The herbs used in vertigo includes:
The main role of herbal medicine offers a multi targeted approach by addressing vascular insufficiency, inflammation and inner ear disfunction making them useful for long term management and can be combined with conventional therapies into patient outcomes.[34]
Herbs used in vertigo
|
Herb Name |
Major Chemical Constituents |
Type of Vertigo Treated |
Mechanism of Action |
Pharmacological Action |
|
Ginkgo biloba |
Flavonoids, Ginkgolides, Bilobalide |
Vestibular vertigo, Meniere’s disease |
Improves cerebral & inner ear blood flow, antioxidant |
Neuroprotective, vasodilatory [35] |
|
Ginger (Zingiber officinale) |
Gingerols, Shogaols, Zingerone |
Motion sickness–induced vertigo |
5-HT3 receptor antagonist, reduces vestibular sensitivity |
Anti-emetic, anti-inflammatory [36] |
|
Peppermint (Mentha piperita)
|
Menthol, Menthone, Rosmarinic acid |
Motion sickness, nausea vertigo |
Calcium channel modulation, CNS effect |
Antispasmodic, antiemetic[37] |
|
Turmeric (Curcuma longa) |
Curcumin, Turmerone, Zingiberene |
Vestibular migraine, inflammatory vertigo |
NF-κB inhibition, antioxidant |
Anti-inflammatory, neuroprotective[38] |
|
Coriander (Coriandrum sativum) |
Linalool, Flavonoids, Coumarins |
Anxiety-related vertigo |
GABAergic modulation, antioxidant |
Anxiolytic, neuroprotective[39] |
|
Valerian (Valeriana officinalis) |
Valerenic acid, Alkaloids, Iridoids |
Stress/anxiety vertigo |
Enhances GABA activity |
Sedative, anxiolytic[40] |
|
Brahmi (Bacopa monnieri) |
Bacosides A & B, Alkaloids |
Vestibular migraine, cognitive-related vertigo |
Enhances cholinergic transmission, antioxidant |
Cognitive enhancer, adaptogen[41] |
|
Cinnamon (Cinnamomum zeylanicum) |
Cinnamaldehyde, Eugenol, Proanthocyanidins |
Circulatory vertigo |
Improves blood flow, CNS stimulation |
Circulatory stimulant, antioxidant[42] |
|
Ashwagandha (Withaniasomnifera) |
Withanolides, Alkaloids |
Stress-related vertigo |
Reduces cortisol, neuroprotective |
Adaptogen, anxiolytic[43] |
|
Tulsi (Ocimum sanctum) |
Eugenol, Ursolic acid, Rosmarinic acid |
Stress & inflammatory vertigo |
Antioxidant, reduces oxidative stress in CNS |
Adaptogen, anti-inflammatory[44] |
|
Chamomile (Matricaria chamomilla) |
Apigenin, Bisabolol, Flavonoids |
Anxiety-related vertigo |
Binds benzodiazepine receptors, GABA agonist |
Sedative, anxiolytic[45] |
|
Garlic (Allium sativum) |
Allicin, Sulfur compounds, Flavonoids |
Circulatory vertigo, atherosclerotic vertigo |
Improves blood circulation, reduces cholesterol |
Antiplatelet, cardioprotective[46] |
|
Lemon balm (Melissa officinalis) |
Rosmarinic acid, Citral, Flavonoids |
Anxiety & sleep-related vertigo |
Enhances GABAergic activity |
Sedative, anxiolytic[47] |
|
Gotu kola (Centella asiatica) |
Asiaticoside, Madecassoside, Triterpenes |
Cognitive impairment–related vertigo |
Enhances neuronal repair, antioxidant |
Neuroprotective, cognitive enhancer [48] |
|
Licorice (Glycyrrhiza glabra) |
Glycyrrhizin, Flavonoids, Saponins |
Meniere’s disease, vestibular vertigo |
Anti-inflammatory, cortisol modulation |
Anti-inflammatory, immunomodulator [49] |
|
Cardamom (Elettaria cardamomum) |
Cineole, Terpenes, Flavonoids |
Nausea & dizziness vertigo |
CNS stimulation, improves circulation |
Digestive stimulant, antioxidant [50] |
|
Shankhpushpi (Convolvulus pluricaulis) |
Flavonoids, Alkaloids, Coumarins |
Cognitive stress-related vertigo |
Enhances cholinergic activity, antioxidant |
Memory enhancer, anxiolytic[51] |
|
Clove (Syzygium aromaticum) |
Eugenol, Flavonoids, Tannins |
Motion sickness, nausea vertigo |
CNS depressant effect, antioxidant |
Anti-nausea, mild sedative[52] |
|
Feverfew (Tanacetum parthenium) |
Parthenolide, Sesquiterpene lactones |
Vestibular migraine |
Inhibits serotonin release, reduces inflammation |
Antimigraine, anti-inflammatory[53] |
|
Skullcap (Scutellarialateriflora) |
Baicalin, Flavonoids, Alkaloids |
Anxiety-related vertigo |
GABA receptor modulation, CNS calming |
Sedative, anxiolytic[54] |
Safety, side effects and herb drug interactions
Gingko biloba turmeric brahmi,valeriam, ashwagandha and pippermentthese are used as herbal medicine for vertigo these are generally safe when consumed recommended therapeutic doses. The safety depends on some factors such as dosage and duration of use prolonged or high dose consumption may lead to toxicity
CAUTION
Majorly required in children, pregnant or lactating women, elderly patients and individuals affected with liver or kidney disorders.
Side Effects of Herbs Used in Vertigo
1. Ginkgo biloba:
2. Ginger (Zingiber officinale):
3. Turmeric (Curcuma longa):
4. Bacopa monnieri (Brahmi):
5. Valerian (Valeriana officinalis):
6. Ashwagandha (Withania somnifera):
7. Peppermint (Mentha piperita):
Herb–Drug Interactions
Potentiates the effect of anticoagulants (warfarin, heparin), antiplatelet agents (aspirin, clopidogrel), and NSAIDs → ↑ bleeding risk. May interact with anticonvulsants, decreasing seizure threshold.
Enhances the effect of anticoagulants and antiplatelet drugs ↑ bleeding risk. Lowers blood sugar levels, care for diabetic patients. Potentiates antihypertensive drugs, leading to hypotension.
Interacts with anticoagulants (warfarin, aspirin), enhancing bleeding tendency. May interfere with drugs affecting liver metabolism (CYP enzymes).May reduce the effectiveness of proton pump inhibitors and increase risk of GI upset with NSAIDs.
Enhances sedative and hypnotic effects when combined with CNS depressants (benzodiazepines, antihistamines, barbiturates). May potentiate thyroid hormone replacement therapy.
Potentiates sedatives, hypnotics, alcohol, antidepressants, and antihistamines causes excessive CNS depression. Should be avoided with anesthesia due to additive depressant effect.
Use of benzodiazepines, barbiturates, or alcohol causes sedative effect. Can interact with immunosuppressants, thyroid medications, and antihypertensive drugs.
May reduce absorption of certain drugs by accelerating gastric emptying. Can inhibit cytochrome P450 enzymes, leading to altered drug metabolism. Interacts with antacids and proton pump inhibitors.[55]
CONCLUSION
Vertigo is a frequent neurological symptom defined as an illusory sensation of spinning, imbalance, and dizziness and is generally accompanied by nausea, vomiting, and psychological distress. It can affect from various causes including inner ear disorder, central nervous system disorder, vascular insufficiency, or psychosomatic causes. Traditional pharmacologic treatment consists of vestibular suppressants, antihistamines, antiemetics, and anxiolytics, which exert relief that is temporary but accompanies side effects in the form of sedation, dependency, and symptom relapse. This has generated interest in safer and natural options like herbal remedies, which are traditionally accepted in systems of traditional medicine and increasingly researched in contemporary pharmacology.
Some medicinal plants have been traditionally and scientifically documented to be involved in the management of vertigo. Ginkgo biloba is a most studied herb, which improves cerebral circulation, attenuates oxidative stress, and enhances balance disorders, especially in Meniere's disease and vertigo of vascular origin. Zingiber officinale or ginger is a well-documented herb with antiemetic, anti-inflammatory, and vestibular-modulating action and is very effective in motion sickness and vertigo with nausea. Withania somnifera (ashwagandha), Bacopa monnieri (brahmi), and Centella asiatica (gotu kola) are adaptogens and neuroprotective substances that counteract stress, anxiety, and cognitive impairment, which usually exacerbate vertigo symptoms. Coriandrum sativum, Glycyrrhiza glabra, Tinospora cordifolia, and Convolvulus pluricaulis are also mentioned in Ayurveda and Unani texts for their action of soothing the nervous system, enhancing blood flow, and maintaining ear health.
The modes of action of these herbs are varied and comprise vasodilation, antioxidant activity, anti-inflammatory action, modulation of neurotransmitters, neuroprotection, and facilitation of vestibular function. In contrast to synthetic medications, which tend to affect one pathway only, herbal preparations affect many physiological processes and thus are especially appropriate for a multifactorial symptom such as vertigo. In addition, their safety profile, low cost, and cultural acceptability contribute to their therapeutic utility.
But challenges persist in their use in the clinic. The majority of studies available are small-scale clinical trials or preclinical studies, and few large, well-controlled studies exist to determine efficacy. Problems with consistency in phytochemical content, dosing, and possible herb–drug interactions (e.g., ginkgo with anticoagulants, ginger with antiplatelet drugs) need to be resolved before these remedies become a part of mainstream medicine.
In summary, herbal medicine presents a promising complementary intervention for the management of various forms of vertigo. By leveraging traditional information with contemporary scientific investigation, natural therapies have the potential to improve patient outcomes, decrease reliance on chemical drugs, and create a holistic approach to the management of balance disorders. Future research aimed at standardization, pharmacological validation, and clinical trials will be invaluable in ensuring their evidence-based place in vertigo management.
REFERENCES
Dr. T. Harika, J. Lulika Kumari, J. Ambika, B. Nagavamsi, B. Thrishank Kumar, A Full Review of Herbal Remedies for Managing Different Types of Vertigo, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 9, 2344-2359. https://doi.org/10.5281/zenodo.17168587
10.5281/zenodo.17168587